Results 171 to 180 of about 248,720 (268)

Yardstick competition under fiscal and administrative asymmetries: Rent‐seeking and local cooperation

open access: yesAnnals of Public and Cooperative Economics, EarlyView.
Abstract This paper develops a two‐period model to investigate how fiscal and bureaucratic asymmetries shape yardstick competition (YC), inter‐municipal cooperation (IMC), and rent‐seeking in local public service provision. Unlike previous approaches, we allow incumbents to invest in bureaucratic efficiency, influencing both service quality and ...
Antonio Cortese   +2 more
wiley   +1 more source

Comparative effectiveness of apalutamide‐, abiraterone‐, and enzalutamide‐based doublets in mHSPC

open access: yesBJU International, EarlyView.
Background and Objective Treatment of metastatic hormone‐sensitive prostate cancer (mHSPC) has evolved from androgen‐deprivation therapy (ADT) alone to combination therapy with androgen receptor pathway inhibitors. Although apalutamide (APA), abiraterone (ABI), and enzalutamide (ENZA) improve outcomes when added to ADT, direct comparative trials ...
Anikó Katalin Valikovics   +9 more
wiley   +1 more source

Spatial evolution of microglial phenotypes and iron accumulation in CSF1R‐associated leukoencephalopathy

open access: yesBrain Pathology, EarlyView.
CSF1R‐LE autopsy tissue shows early loss of homeostatic microglia and inflammatory myeloid activation in mildly damaged regions, with progressive iron accumulation paralleling white matter damage and myelin degeneration without remyelination. This spatially heterogeneous pathology suggests cellular iron accumulation might accompany or even drive ...
Julia Lier   +15 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Cancer pain: current practice and emerging targets

open access: yesBritish Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye   +5 more
wiley   +1 more source

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