Results 51 to 60 of about 323 (61)

Traditional Chinese medicine bufalin inhibits infectious hematopoietic necrosis virus infection in vitro and in vivo. [PDF]

Microbiol Spectr
Zhao J-Z, Xu L-M, Li L-F, Ren G-M, Shao Y-Z, Liu Q, Lu T-Y.   +6 more
europepmc   +1 more source

Simplified Method for Kinetic and Thermodynamic Screening of Cardiotonic Steroids through the K⁺-Dependent Phosphatase Activity of Na⁺/K⁺-ATPase with Chromogenic pNPP Substrate. [PDF]

Mol Pharmacol
Azalim-Neto P, Noël F, Silva SC, Villar JAFP, Barbosa L, O'Doherty GA, Quintas LEM.   +6 more
europepmc   +1 more source

Hellebrigenin induces oral cancer cell apoptosis by modulating MAPK signalling and XIAP expression. [PDF]

J Cell Mol Med
Hsieh MJ, Lin CC, Lo YS, Ho HY, Chuang YC, Chen MK.   +5 more
europepmc   +1 more source

Multi-b-value DWI to evaluate the synergistic antiproliferation and anti-heterogeneity effects of bufalin plus sorafenib in an orthotopic HCC model. [PDF]

Eur Radiol Exp
Guo R, Lu F, Lin J, Fu C, Liu M, Yang S.
europepmc   +1 more source

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Investigation of cytotoxic effect of the bufanolide steroid compound cinobufagin and its related underlying mechanism in brain cell models

Journal of Biochemical and Molecular Toxicology, 2021
AbstractCinobufagin, a bufadienolide of toad venom of Bufo bufo gargarizans, is used as a cardiotonic, central nervous system (CNS) respiratory agent, as well as an analgesic and anesthetic. However, several research showed that bufadienolide has a few side effects on the CNS, such as breathlessness or coma.
Shu‐Shong Hsu, Yung‐Shang Lin, Wei‐Zhe Liang   +2 more
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Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, suppresses hERG K⁺ currents expressed in HEK293 cells

Fundamental & Clinical Pharmacology, 2017
AbstractIn this study, we investigated the effect of bufalin on the human ether‐à‐go‐go‐related gene (hERG) K+ channels using the perforated patch recording technique. We measured a half‐maximal inhibitory concentration (IC50) of 24.83 μM and maximal inhibitory effect of 39.45 ± 1.14% with bufalin. These findings suggest that bufalin is a potent hERG K+
Tao Song, Yuanyuan Zhang, Qiongtao Song, Xue Han, Shengjiang Guan, Xuan Zhang, Xi Chu, Fenghua Zhang, Jianping Zhang, Li Chu   +9 more
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ChemInform Abstract: BUFADIENOLIDE 10. MITT. 3BETA‐ACETOXY‐14BETA,21‐EPOXY‐5BETA‐BUFANOLIDE UND VERWANDTE LACTONE

Chemischer Informationsdienst. Organische Chemie, 1970
AbstractUmsetzung des Norcholansäuremethylesters (I) mit konz. Salzsäure (in Essig= Säure (über Nacht bei Zimmertemperatur) ergibt Isodigitoxigenin (II), analoge Umsetzung des Acetals (III) ergibt nach Remethylierung, Reacetylierung und nach säulenchromatographischer Trennung den Vinyläther (IV) (42% Ausbeute), 3β ,(21R)‐Diacetoxy‐l4ß,21‐epoxy‐5ß,(2OS)‐
J. C. KINGHT, G. R. PETTIT, P. BROWN
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Bufalin, a bufanolide steroid from the parotoid glands of the Chinese toad, inhibits L‐type Ca²⁺ channels and contractility in rat ventricular myocytes

Fundamental & Clinical Pharmacology, 2017
AbstractBufalin is a bufanolide steroid compound in Chan Su. Chan Su is a traditional Chinese medicine prepared from the dried white secretion of the auricular and skin glands of toads and has been used as an oriental drug. However, the effect of bufalin on cardiac function and its underlying cellular mechanisms remain unclear.
Tao, Song, Xi, Chu, Xuan, Zhang, Qiongtao, Song, Ying, Zhang, Yuanyuan, Zhang, Xue, Han, Jianping, Zhang, Li, Chu   +8 more
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Steroids and related natural products. LVII. Bufadienolides. 10. 3.beta.-Acetoxy-14.beta.,21-epoxy-5.beta.-bufanolide and related lactones

The Journal of Organic Chemistry, 1970
John C. Knight, George R. Pettit, Peter Brown   +2 more
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Bufadienolides. 10. 3-beta-acetoxy-14-beta,21-epoxy-5-beta-bufanolide and related lactones.

The Journal of organic chemistry, 1970
J C, Knight, G R, Pettit, P, Brown
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