Results 121 to 130 of about 2,471,677 (248)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Development of a network buffer for a Quantum Random Number Generator
openQuesta tesi presenta lo sviluppo di un buffer di rete generalizzato per la distribuzione in tempo reale degli eventi generati da un QRNG (Quantum Random Number Generator) e acquisiti tramite tre timetagger diversi (fake, quTAG, Swabian). Inizialmente
GOBBO, LORENZO KAROL
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Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Buffer-aided link selection with network coding in multihop networks
, 2016 © 2015 IEEE.This paper proposes a novel buffer-aided link selection scheme based on network coding in the multiple-hop relay network. The proposed scheme significantly increases transmission throughput by applying data buffers at the relays to decrease ...
Gaojie Chen (7211195) +4 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The Buffer-Stock Theory of Saving: Some Macroeconomic Evidence [PDF]
macroeconomics, Buffer-Stock Theory of Saving ...
Christopher D. Carroll
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Interoperational buffer sizing: an application between production lines and departments
openLa tesi si concentra sull'analisi di un caso studio riguardante l'ambito di studi degli Impianti Meccanici. Dopo aver introdotto i concetti più teorici in modo da descrivere le fondamenta su cui si baserà poi il l'elaborato finale si passerà all ...
GIORDANELLI, MARTA
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