Results 141 to 150 of about 7,100,747 (295)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Interoperational buffer sizing: an application between production lines and departments
openLa tesi si concentra sull'analisi di un caso studio riguardante l'ambito di studi degli Impianti Meccanici. Dopo aver introdotto i concetti più teorici in modo da descrivere le fondamenta su cui si baserà poi il l'elaborato finale si passerà all ...
GIORDANELLI, MARTA
core
THE BUFFER ROLE OF GROUNDWATER WHEN SURFACE WATER SUPPLIES ARE UNCERTAIN: THE IMPLICATIONS FOR GROUNDWATER DEVELOPMENT [PDF]
When used in conjunction with surface water for irrigation, groundwater serves two roles: to increase water supply; and to mitigate fluctuations in the supply of water. The later is the buffer role.
Tsur, Yacov
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Recent advances in designing high-performance and enzymatically degradable plastics. [PDF]
Chem SciLiu J, Zhou X, Uyama H, Takashima Y.
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Endangered <i>Salvia daiguii</i> Has Evolved Drought Tolerance Through Photosynthetic, Antioxidant, and Respiratory Adaptations: Implications for Ex Situ Propagule Reintroduction. [PDF]
Plants (Basel)Xie C +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Peroxyl radical-mediated oxidative crosslinking of faba and pea proteins: Differential aggregation behavior and implications for protein structuring. [PDF]
Food Chem XCamus J +3 more
europepmc +1 more source