Results 41 to 50 of about 28,472 (266)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
On the Impact of Refactorings on Software Attack Surface
IEEE AccessRefactoring is one of the techniques mostly employed by software developers to improve the quality attributes of their systems. However, little has been done to investigate how refactoring operations specifically aimed at improving the internal structure
Estomii Edward +2 more
doaj +1 more source
Infestation by pyrethroids resistant bed bugs in the suburb of Paris, France
Parasite, 2012 Bed bugs are hematophagous insects responsible for a re-emerging and challenging indoor pest in many countries. Bed bugs infestations may have health consequences including nuisance biting, cutaneous and systemic reactions.
Durand R. +6 more
doaj +1 more source
MLSA: a static bugs analysis tool based on LLVM IR [PDF]
International Journal of Networked and Distributed Computing (IJNDC), 2016 Program bugs may result in unexpected software error, crash or serious security attack. Static program analysis is one of the most common methods to find program bugs.
Hongliang Liang +3 more
doaj +1 more source
PLoS ONE, 2023 Aelia fieberi Scott, 1874 is a pest of crops. The mitogenome of A. fieberi (OL631608) was decoded by next-generation sequencing. The mitogenome, with 41.89% A, 31.70% T, 15.44% C and 10.97% G, is 15,471 bp in size.
Qianquan Chen +5 more
doaj +1 more source
Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito +14 more
wiley +1 more source
Parasites & Vectors, 2021 Background Triatomine bugs, the vectors of Chagas disease, associate with vertebrate hosts in highly diverse ecotopes. It has been proposed that occupation of new microhabitats may trigger selection for distinct phenotypic variants in these blood-sucking
Fernando Abad-Franch +9 more
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
How Climate Model Developers Deal With Bugs
Earth's FutureGeneral circulation models (GCMs) are not only powerful tools to understand Earth's climate system and to forecast the weather. They are also large software programs written by humans. As such, they contain coding mistakes, so‐called bugs.
Ulrike Proske, Lieke A. Melsen
doaj +1 more source