Results 91 to 100 of about 9,237,687 (277)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
"Build, build, build" - new permitted development rights [PDF]
, 2020 Reviews reforms to the Town and Country Planning (General Permitted Development) (England) Order 2015 Pt 20, to permit construction of up to two extra storeys on many purpose-built blocks of flats, without planning permission. Examines the restrictions on the permitted development right, the factors relevant to prior approval applications, the role of ...
openaire
Building a Learning Organization [PDF]
, 2009 {Excerpt} A learning organization values the role that learning can play in developing organizational effectiveness. It demonstrates this by having an inspiring vision for learning and a learning strategy that will support the organization in achieving ...
Serrat, Olivier
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Building a Cleaner World [PDF]
, 2016 Korupsi dalam artian luas telah menembus semua zona dan lapisan hidup sosialmasyarakat. Suburnya korupsi mencerminkan lemahnya suatu sistem pemerintahan yangmemungkinkan tindakan koruptif yang merugikan banyak orang.
CHANG, W. (WILLIAM)
core
, 2004 We construct N=1 and N=0 chiral four-dimensional vacua of flux compactification in Type IIB string theory. These vacua have the common features that they are free of tadpole instabilities (both NSNS and RR) even for models with N=0 supersymmetry.
A. Giryavets +61 more
core +2 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Building Commons Governance for a Greener Economy [PDF]
, 2015 Much recent work in ecological economics and political ecology, including calls for “de-growth” in the transition towards more sustainable economies, focuses on commons as a promising paradigm for sustainable governance institutions. The vision involves
Perkins, Patricia E. (Ellie)
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