Results 61 to 70 of about 9,390,692 (295)
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Advancing Ecohealth in Southeast Asia and China: Lessons from the Field Building Leadership Initiative [PDF]
International Development Research ...
Field Building Leadership Initiative
core +1 more source
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Evaluative Language and Its Solidarity-Building Role on TED.com: An Appraisal and Corpus Analysis [PDF]
Language is a key resource in the formation of online communities, which are in turn central to an understanding of contemporary social relations. This study looks at TED.com, an educational video-hosting platform with few in-built community-building ...
Drasovean, Anda, Tagg, Caroline
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The more AI agents are deployed in scenarios with possibly unexpected situations, the more they need to be flexible, adaptive, and creative in achieving the goal we have given them.
Mattei, Nicholas, Rossi, Francesca
core +1 more source
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Murphy is a set of techniques and tools under investigation for their potential in enhancing the safety of software.
Leveson, Nancy G.
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Building Campaign Update [PDF]
Three alums have spearheaded the new building effort and the law school community has happily followed their lead. Although groundbreaking is slated for October and $7.5 million has been pledged, there is still much to be done.
Hart, Chris
core +1 more source

