Results 71 to 80 of about 1,266,933 (305)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Building governance and energy efficiency: Mapping the interdisciplinary challenge [PDF]

, 2018
Improving the energy efficiency of multi-owned properties (MoPs)—commonly known as apartment or condominium buildings—is central to the achievement of European energy targets. However, little work to date has focused on how to facilitate retrofit in this
AB Jaffe, David Weatherall, E Fox, E Hirst, FF Sniehotta, H Tajfel, I Ajzen, JM Darley, K Raworth, KB Janda, L Lutzenhiser, M Crozier, MP Lefeuvre, RJ Sampson, S Bright, S Sorrell   +15 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Efficacy of Accelerated Carbonation Curing and Its Influence on the Strength Development of Concrete

Buildings
The building sector is figuring out how to lower its embodied CO2 in a sustainable way. The technology, known as Carbon Capture, Utilization, and Storage (CCUS), offers a possible remedy for this issue.
Akarsh Padmalal, Kishor S. Kulkarni, Pradeep Rawat, H. K. Sugandhini   +3 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Analysis of a residential building energy consumption as “base model” in Tripoli, Lebanon [PDF]

, 2016
The interest in energy performance of buildings in Lebanon has increased in the last few years. Indeed, many organizations are evaluating the commercial buildings’ energy performance in order to increase the commercial sector energy efficiency.
Yathreb, S.
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Prospective dynamic average and marginal electricity emission factors for Germany until 2070: a methodological extension incorporating energy storage

Energy, Sustainability and Society
Background Life Cycle Assessment (LCA) of electricity consumption requires temporally resolved emission factors. Two established metrics are the Average Emission Factor (AEF), allocating total system impacts to consumed electricity, and the Marginal ...
Tobias Blanke, Joachim Göttsche, Bernd Döring, Jérôme Frisch, Christoph van Treeck   +4 more
doaj   +1 more source

Thermal Performance Optimization and Experimental Evaluation of Vacuum-Glazed Windows Manufactured via the In-Vacuum Method

Energies, 2019
Windows are essential in buildings; however, they have poor thermal performance, so extensive research has been conducted on improving their performance. In this study, we developed vacuum-glazed windows with excellent insulation via the in-vacuum method,
Jaesung Park, Myunghwan Oh, Chul-sung Lee   +2 more
doaj   +1 more source