Results 221 to 230 of about 2,960,965 (353)

mTORC2 Phosphorylation of GSDME‐N Drives Cullin4B‐Mediated Proteasomal Degradation to Suppress Pyroptosis and Confer Radioresistance in Small Cell Lung Cancer

Advanced Science, EarlyView.
Radioresistance severely limits the efficacy of therapies for small cell lung cancer (SCLC). This study reveals a novel mechanism of resistance driven by the active suppression of pyroptosis. Specifically, the mTORC2 complex directly phosphorylates GSDME‐N and promotes its CUL4B‐mediated ubiquitination and proteasomal degradation.
Qing‐qing Xu, Ci‐ming Sun, Sui‐xian Zhang, Rui Li, Chen‐fei Wu, Zai‐shan Lin, Li Li, Run‐zhe Chen, Qi‐wen Li, Yuan‐yuan Chen, Xuan Li, Ming Chen   +11 more
wiley   +1 more source

Deployable knowledge-data hybrid models for day-ahead cooling load prediction under data scarcity: a case study and performance validation. [PDF]

Sci Rep
Chen J, Sun T, Zhang Y, Zhang W, Chen L, Liu W, Gao W, Xu T.   +7 more
europepmc   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Techno-economic assessment of retrofit pathways towards near zero-energy performance in a Saudi residential villa. [PDF]

Sci Rep
Aloshan M, Aldali K.
europepmc   +1 more source

Beyond d‐Band Catalysis: A Critical Review and Descriptor Framework for Rare‐Earth Engineering in Lithium–Sulfur Batteries

Advanced Science, EarlyView.
Rare‐earth catalysts regulate lithium–sulfur battery chemistry through f‐orbital–mediated interactions, enabling simultaneous polysulfide adsorption and catalytic conversion on conductive carbon hosts. This synergistic control suppresses the shuttle effect, accelerates redox kinetics, and guides stable Li2S nucleation, providing a mechanistic framework
Fan Wang, Shihzad Shakil, Guozhi Wu, Jiarui Huang, Hanhui Lei, Terence Xiaoteng Liu   +5 more
wiley   +1 more source

Design optimization of office building envelope by developed farmland fertility algorithm for energy saving.

Heliyon
Yang C, Yu S, Cao Y, Abdolhosseinzadeh S.   +3 more
europepmc   +1 more source

A GAN-physical simulation coupled framework for joint optimization of building energy prediction and spatial configuration. [PDF]

Sci Rep
JinYan L.
europepmc   +1 more source

Unconventional Hysteretic Charge Filling in Moiré‐Reconstructed Helical Trilayer Graphene

Advanced Science, EarlyView.
In helical trilayer graphene, sequential twisting reconstructs the moiré landscape into periodic domains separated by aperiodic boundaries. Longitudinal transport reveals sweep‐direction‐dependent hysteresis, while the Hall response traces this behavior to hysteretic charge filling at the aperiodic boundaries.
Hangyeol Park, Junhyeok Oh, Rasoul Ghadimi, Chiranjit Mondal, Yungi Jeong, Won Beom Choi, Kenji Watanabe, Takashi Taniguchi, Bohm‐Jung Yang, Joonho Jang   +9 more
wiley   +1 more source

An AI-driven multi-objective framework for optimizing window dimensions considering energy demand and thermal comfort. [PDF]

Sci Rep
Nasab SMRA, Rabiei H.
europepmc   +1 more source

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source