Results 31 to 40 of about 160,049 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dynamic Inversion Method of Calculating Large-Scale Urban Building Height Based on Cooperative Satellite Laser Altimetry and Multi-Source Optical Remote Sensing

Land
Building height is a crucial indicator when studying urban environments and human activities, necessitating accurate, large-scale, and fine-resolution calculations.
Haobin Xia, Jianjun Wu, Jiaqi Yao, Nan Xu, Xiaoming Gao, Yubin Liang, Jianhua Yang, Jianhang Zhang, Liang Gao, Weiqi Jin, Bowen Ni   +10 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Advances on the Global Human Settlement Layer by joint assessment of Earth Observation and population survey data

International Journal of Digital Earth
The Global Human Settlement Layer (GHSL) project fosters an enhanced, public understanding of the human presence on Earth. A decade after its inception in the Digital Earth 2020 vision, GHSL is an established project of the European Commission’s Joint ...
Martino Pesaresi, Marcello Schiavina, Panagiotis Politis, Sergio Freire, Katarzyna Krasnodębska, Johannes H. Uhl, Alessandra Carioli, Christina Corbane, Lewis Dijkstra, Pietro Florio, Hannah K. Friedrich, Jing Gao, Stefan Leyk, Linlin Lu, Luca Maffenini, Ines Mari-Rivero, Michele Melchiorri, Vasileios Syrris, Jamon Van Den Hoek, Thomas Kemper   +19 more
doaj   +1 more source

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

UPDATING BUILDING MAPS BASED ON OBJECT EXTRACTION AND BUILDING HEIGHT ESTIMATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2012
This study presents a novel approach in building change detection for map updating in urban areas. Our approach is based on the integration of building object extraction and building height estimation utilizing existing 2D building maps and newly ...
L. Zhu, H. Shimamura, K. Tachibana
doaj   +1 more source

A Novel KCNA1 Variant in a Patient With Tremor and Autism Spectrum Disorder Causes Mixed LOF/GOF Defects of Kv1.1 Channels

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Variants in KCNA1, encoding the Kv1.1 potassium channel, cause neurological disorders including episodic ataxia and developmental and epileptic encephalopathy. We identified a novel KCNA1 variant (A401T) in a 16‐year‐old patient with autism spectrum disorder, borderline intellectual disability, and tremor, without episodic ataxia or epilepsy ...
Juan Darío Ortigoza‐Escobar, Laura Marti‐Sánchez, Loreto Martorell, Giorgia Dinoi, Antonio Vittorio Buono, Annamaria De Luca, Antonella Liantonio, Paola Imbrici   +7 more
wiley   +1 more source

A Systematic Review of the Potential Influence of Urbanization on the Regional Thunderstorm Process and Lightning Activity

Atmosphere
In the context of global climate change, lightning disasters have emerged as a serious environmental factor that restricts the sustainable development of megacities.
Tao Shi, Gaopeng Lu, Xiangcheng Wen, Lei Liu, Ping Qi   +4 more
doaj   +1 more source

Shadow Pattern-Enhanced Building Height Extraction Using Very-High-Resolution Image

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, 2023
Building height is valuable for a variety of foci in urban studies. The traditional field investigations are not practical for the updates of massive building height in a large-scale urban area.
Xiran Zhou, Soe W. Myint
doaj   +1 more source