Results 241 to 250 of about 241,946 (291)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Object Recognition-Based Grasping with a Soft Modular Gripper. [PDF]

Biomimetics (Basel)
Zhang Y, Zhang F, Guo Z, Luan L, Sui D, Wang T, Zhou J, Zhang F, Chen C, Li D, You B.   +10 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

DFENet: A Novel Dual-Path Feature Extraction Network for Semantic Segmentation of Remote Sensing Images. [PDF]

J Imaging
Cao L, Liu Z, Wang Y, Gao R.
europepmc   +1 more source

A Solution for Heritage Monitoring Based on Wireless Low-Cost Sensors and BIM: Application to the Monserrate Palace. [PDF]

Sensors (Basel)
Machete R, Dias FM, Caetano DM, Falcão AP, Gomes MDG, Bento R.   +5 more
europepmc   +1 more source

20 Years of the ISCB Student Council Symposium: shaping computational biology and future leaders. [PDF]

Bioinform Adv
Fernandez-Martin M, Castillo-Orozco A, Poley-Gil M, Pose-Lagoa I, Urquiza-Zurich S, Hayoun-Mya O, Machado-Reyes D, Treccani M, Veschetti L, Carvajal-Agudelo JD, Boll LM, Garcia-Valiente A, Parra RG, Olguín-Orellana GJ.   +13 more
europepmc   +1 more source

BGSC-Net: Boundary-guided semantic compensation network for remote sensing image segmentation. [PDF]

PLoS One
Wang X, Lu Z, Yang Q, Lu J, Yang H, Qin Q, Lian G, Wang J.   +7 more
europepmc   +1 more source

Automated building energy modeling for energy retrofits using a large language model-based multi-agent framework. [PDF]

iScience
Lu J, Zheng Z, Langtry M, Jackson M, Zhao Y, Feng C, Zhang R, Zhang C, Zhang J, Choudhary R.   +9 more
europepmc   +1 more source