Results 101 to 110 of about 1,952 (206)

Meta‐Analysis of Imatinib Resistance in Chronic Myeloid Leukemia due to BIM Gene Deletion and Single Nucleotide Polymorphisms Reveals Ethnic Variations in Prevalence

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Background and Aim Deletion and single nucleotide polymorphisms in the BIM gene have been proposed as a potential contributor of intrinsic resistance to imatinib in patients with chronic myeloid leukemia (CML). Individual studies, particularly in East Asian population, have reported higher frequency of these gene variants and have suggested ...
Abhinav Bhattarai, Dimitri Kountouris, Sanjit Sah, Rachana Mehta, Ranjit Sah   +4 more
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang, Feng‐Li Jiang, Fang‐Yuan Zhang, Dong‐Hui Huang, Xiao‐Ying Li, Song Gao, Hua You, Qi‐Jun Wu, Huan‐Huan Chen, Ting‐Ting Gong   +9 more
wiley   +1 more source

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

‘They are not predators: They are a higher power’—Relational values and principles framing human–predator relationship in Noongar Country, Southwestern Australia

People and Nature, Volume 8, Issue 8, Page 2682-2699, August 2026.
Abstract Human–predator coexistence presents urgent conservation challenges that demand approaches extending beyond mere conflict mitigation. Indigenous knowledge systems, though historically marginalised by Western science, offer vital insights into ethical, sustainable relationships with nature.
Rocío Almuna, Cristina E. Ramalho, Lynette Knapp, Carol Pettersen, Iris Maude Bonshore, Elizabeth M. Woods, Gail E. Yorkshire‐Selby, Mick Hayden, Rhys Bonshore, Larry Blight, Peter Speldewinde, José Tomás Ibarra, Stephen D. Hopper   +12 more
wiley   +1 more source

Building Information Modeling (BIM)

, 2016
Los procesos de diseño y construcción tradicionales de la industria de la construcción que se han conservado inalterados durante años, han impedido vislumbrar los impactos positivos que se pueden dar al trabajar en conjunto con las tecnologías de información -- El miedo al cambio hace que las empresas del sector denominen “normal” a la fragmentación ...
openaire   +1 more source

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Attraction of nocturnal scarab beetles by unusual floral volatiles in a Banksia (Proteaceae) with functionally diverse pollinators

Plant Biology, Volume 28, Issue 5, Page 1454-1466, August 2026.
Banksia attenuata (Proteaceae) attracts nocturnal scarab beetles with an unusual floral scent—the beetles pollinate the flower as they feed on pollen and nectar and mate on the inflorescences. Abstract Pollination by beetles has evolved multiple times in flowering plants but with relatively few plant species adapted specifically to pollination by ...
S. K. Wawrzyczek, B. Bohman, S. L. Krauss, I. M. Butler, G. R. Flematti, K. Farnier, S. E. Hoebee, R. A. Davis, R. D. Phillips   +8 more
wiley   +1 more source

Building Information Modeling (BIM) In High Rise Building

Abstract: This research paper explores the application of Building Information Modeling (BIM) in the context of high- rise building construction. High-rise structures present unique challenges due to their scale and complexity, which traditional construction methods often struggle to manage effectively.
Dr. Krishan Kumar Saini, Prashasti Maharshi, Kapil Gandhi   +2 more
openaire   +1 more source

Correction: Ma et al. Generative Design in Building Information Modelling (BIM): Approaches and Requirements. <i>Sensors</i> 2021, <i>21</i>, 5439. [PDF]

Sensors (Basel)
Ma W, Wang X, Wang J, Xiang X, Sun J.
europepmc   +1 more source