Results 71 to 80 of about 225,032 (265)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The strategy of performing maintenance work and its impact on maintaining the efficiency of schools’ operation [PDF]

Fayoum University Journal of Engineering
This research aims to develop a strategy for various maintenance works inside buildings, whether planned, emergency, or remedial maintenance, with the aim of preserving the building and increasing its operational efficiency.
Nader Ismael
doaj   +1 more source

Scenarios for Maintenance and Building Decommissioning in the Building’s Life Cycle

IOP Conference Series: Earth and Environmental Science, 2019
The LCC analysis can be applied to assess effectiveness of construction variants or acquisition of new facilities as well as modernization of the existing ones. The authors of this paper intended to apply the LCCA method at analysing a building in the final stage of the building life cycle (grade phase).
E. Plebankiewicz, K. Zima, D. Wieczorek
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Inadequate housing in Ghana [PDF]

Urbani Izziv, 2011
Two themes are evident in housing research in Ghana. One involves the study of how to increase the number of dwellings to correct the overall housing deficit, and the other focuses on how to improve housing for slum dwellers.
Franklin Obeng-Odoom, Laurence Amedzro
doaj  

Study on the Construction Performance of Zeolite Asphalt Mixture Based on Macro-Micro Scale

Advances in Materials Science and Engineering, 2020
In order to explore the construction performance of zeolite asphalt mixture, the microproperties of zeolite and the macroproperties of zeolite asphalt mixture were studied.
Zhuolin Li, Junda Ren, Jianping Zhu, Wei Li, Xingsheng Fu, Liying Yang   +5 more
doaj   +1 more source

Building Facade Maintenance

Vestnik Tomskogo gosudarstvennogo arkhitekturno-stroitel'nogo universiteta. JOURNAL of Construction and Architecture
The article is devoted to the problem of providing access to building facades in order to maintain their operational characteristics.Purpose: The purpose of the study is to identify general principles of building facade maintenance that contribute to typification and unification of solutions, and develop practical recommendations for their application ...
L. D. Morshakova, G. A. Bardina, A. I. Zatsepina   +2 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Buildings Lean Maintenance Implementation Model

Open Engineering, 2016
Abstract Nowadays, companies in global markets have to achieve high levels of performance and competitiveness to stay “alive”.Within this assumption, the building maintenance cannot be done in a casual and improvised way due to the costs related.
Abreu, António, Calado, João Manuel Ferreira, Requeijo, José   +2 more
openaire   +3 more sources