Results 51 to 60 of about 4,215,244 (301)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Operationalisation of Building Inspections and Repair: Systematisation-Based Approach

Applied Sciences
The possibility of diagnosing and repairing specific sets of defects (those with more severe consequences and impact on the degradation of building components) with the same means is considered.
Clara Pereira, Ana Silva
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Systems integration in maintenance engineering [PDF]

, 2000
Integration in maintenance engineering systems provides a potential solution to some complex and conflicting problems. Decision making is often achieved with uncertainty and unknowns, while measuring against conflicting performance criteria.
Ball, Andrew, Starr, A, Starr, A., Ball, A.D.   +3 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A service-life cycle approach to maintenance and energy retrofit planning for building portfolios [PDF]

, 2019
\ua9 2019 The Authors Residential buildings account for almost a quarter of the total energy use in Sweden and building owners are, therefore, under pressure from policy makers to improve the energy performance of their buildings.
Wallbaum, Holger,, Sousanabadi Farahani, Abolfazl, Wallbaum, Holger, Dalenb\ue4ck, Jan-Olof, 6sterbring, Magnus, Dalenbäck, Jan-Olof,, N\ue4geli, Claudio, Sousanabadi Farahani, Abolfazl,, Österbring, Magnus,, Nägeli, Claudio,   +9 more
core   +1 more source

Post-Occupancy Evaluation Data Support for Planning and Management of Building Maintenance Plans

Buildings, 2016
The purpose of this paper is to propose a post-occupancy evaluation (POE) method focused on building maintenance and then to test it on two different sets of residential buildings.
Nelson Bento Pereira, Rui Calejo Rodrigues, Patrícia Fernandes Rocha   +2 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A survey on the implementation of facilities maintenance management system of building in Iran [PDF]

, 2012
The degree of the implementation of building facilities maintenance management (FMM) has a major impact on its performance. As a result, the influence of facilities management on the maintenance of buildings is greater than ever before. The issue related
Amani, Nima, Mohamed Ali, Nasly, Abd Samat, Roslida, Mohammed, Abdul Hakim   +3 more
core   +1 more source