Results 171 to 180 of about 1,677,818 (304)

FAO laboratory mapping tool results analysis for veterinary laboratories from 2012 to 2020: highlights of the gaps, the strengths across Southeast Asia and implications for capacity building activities. [PDF]

Front Vet Sci
Gourlaouen M, Blacksell SD, Kim Le K, Morrissy CJ, Kalpravidh W, Wongsathapornchai K, Motta P, Rangkuti A, Dauphin G, Wiersma L, Tran T, Porfiri L, Mouillé B, Claes F.   +13 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Community-based HyPertension Control (CHPC) in Nepal: Cluster randomized implementation trial protocol. [PDF]

Public Health Pract (Oxf)
Shrestha A, Sapkota S, Timalsena D, Sharma P, Porter AK, Cameron DB, Hagaman A, Neupane D, Dhimal M, Mali S, Poudel L, Sagtani RA, Paneru B, Paudel P, Joshi A, Chaulagain DR, Karmacharya RM, Spiegelman D.   +17 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Remediation of novel sources linked to an outbreak of Legionnaires' disease in a manufacturing facility. [PDF]

J Occup Environ Hyg
Dunn KH, Rinsky JL, Burton N, Feldmann K, Acosta AM, Mohamed HM, Zielinski L, Clemmons NS, Edens C, Bell L, Smith JC, Ritter TL, Willby M, Whisenhunt R, Greer V, Garber MA, Diedhiou A.   +16 more
europepmc   +1 more source

Maintenance and Modernization of Building.

Wood Preservation, 1997
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Design and acceptance assessment of a digital product passport for recycled and natural aggregate concrete elements. [PDF]

PLoS One
Sinning A, Würger S, Guo W, Li W, Miny T, Kleinert T, Classen M, Schlittmeier SJ, Bielak J, Böffel C.   +9 more
europepmc   +1 more source