Results 71 to 80 of about 261,938 (308)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Influence of Climate Conditions on Deficiencies of Building Roofs

Applied Sciences, 2019
Climate conditions affect buildings’ performance and durability. The purpose of this paper is to examine the influence of climate conditions on roof deficiencies. 763 cases of such deficiencies were analyzed in this regard.
Manuel J. Carretero-Ayuso, Alberto Moreno-Cansado, Justo García-Sanz-Calcedo   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Building appraisal, maintenance and preservation

, 1985
Incl. Technology and Conservation 1978 (4/78) 8 ppSIGLEAvailable from British Library Document Supply Centre- DSC:86/14497(Building) / BLDSC - British Library Document Supply CentreGBUnited ...
Bath Univ. (United Kingdom). Dept. of Architecture and Building Engineering, Institution of Structural Engineers (ISE), London (United Kingdom), Royal Inst. of British Architects (RIBA), London (United Kingdom)   +2 more
core  

A Methodological Approach to Assessing Constructability in Building Maintenance and Its Impact on University Quality

Buildings
This study introduces and evaluates an innovative methodology for assessing constructability in the maintenance of university buildings, aiming to improve the quality of academic infrastructure.
Mónica Escate, Doris Esenarro
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Some basilar questions about building maintenance

, 1994
The paper presents some considerations on the usage of several maintenance strategies in relation to building typologies with particular reference to "simple" buildings used as dwellings, and "complex" buildings of the services sector.
CECCHINI, Cecilia
core  

The strategy of performing maintenance work and its impact on maintaining the efficiency of schools’ operation [PDF]

Fayoum University Journal of Engineering
This research aims to develop a strategy for various maintenance works inside buildings, whether planned, emergency, or remedial maintenance, with the aim of preserving the building and increasing its operational efficiency.
Nader Ismael
doaj   +1 more source

Study on the Construction Performance of Zeolite Asphalt Mixture Based on Macro-Micro Scale

Advances in Materials Science and Engineering, 2020
In order to explore the construction performance of zeolite asphalt mixture, the microproperties of zeolite and the macroproperties of zeolite asphalt mixture were studied.
Zhuolin Li, Junda Ren, Jianping Zhu, Wei Li, Xingsheng Fu, Liying Yang   +5 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source