Results 51 to 60 of about 261,938 (308)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Post-Occupancy Evaluation Data Support for Planning and Management of Building Maintenance Plans

Buildings, 2016
The purpose of this paper is to propose a post-occupancy evaluation (POE) method focused on building maintenance and then to test it on two different sets of residential buildings.
Nelson Bento Pereira, Rui Calejo Rodrigues, Patrícia Fernandes Rocha   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Operationalisation of Building Inspections and Repair: Systematisation-Based Approach

Applied Sciences
The possibility of diagnosing and repairing specific sets of defects (those with more severe consequences and impact on the degradation of building components) with the same means is considered.
Clara Pereira, Ana Silva
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Adopting green building constructions in developing countries through capacity building strategy: survey of Enugu State, Nigeria

Sustainable Buildings, 2019
Green building (GB) constructions seeks to address housing demands of the growing populace with better qualities, energy efficiency, using recycled and recyclable materials, improve building lifespan and health of occupants.
Chukwu Daniel Uchenna, Anaele Edmund A., Omeje Hyginus O., Ohanu Ifeanyi B.   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Maintenance Building

, 2020
The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau, Photographer: not known   +1 more
core   +1 more source

BIM implementation in building maintenance management [PDF]

Građevinar, 2019
Building Information Modelling (BIM) podrazumijeva izradu višedimenzionalnog informacijskog modela građevine, koji se temelji na osnovnom 3D modelu i omogućava dijeljenje informacija među sudionicima u projektu tijekom cijelog životnog vijeka građevine. Za učinkovitije upravljanje održavanjem građevina predlaže se integracija održavanja građevina i BIM-
Cerić, Anita, Završki Ivica, Vukomanović, Mladen, Ivić, Ivona, Nahod, Maja-Marija   +4 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source