Results 121 to 130 of about 4,215,244 (301)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Implementation Of Life Cycle Cost in The Bus Station Building

Jurnal Teknik Sipil
With the increase in existing development, of course, there must be consideration of careful cost planning to support planning, use, and the end of the building service period, particularly in the building industry.
Divan Yoan Alvino Damanik
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Role of maintenance in reducing building vulnerability to extreme events

, 2019
The paper is to assess contribution of maintenance toward reducing building vulnerability to extreme weather events such as high wind, wild fire and flood.
Pham, L, Palaneeswaran, E, Stewart, R
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Maintenance Building: Loading bays

, 2020
The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau, Photographer: not known   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Virtual Mining Environment for Providing Dynamic Decision Support for Building Maintenance

, 2005
A virtual mining environment aims to provide dynamic decision support to improve building life-cycle modelling and management. This paper presents the system architecture of a virtual mining environment, its interfaces and a user scenario.
J.S. Gero, R. Reffat
core  

Maintenance Building: Rear entrance

, 2020
The black and white photographs document the early development of the ...
Commonwealth News and Information Bureau, Photographer: not known   +1 more
core  

Influence of Mixing Conditions on the Strength and Microstructure of Cement Paste

Buildings
The conventional “one-pot” mixing method employed in concrete production restricts both efficiency and quality optimization. This study systematically investigates the effects of mixing duration and rotational speed on the compressive strength and ...
Yufan Wan, Hongbo Cao, Guangqiao Zhang, Xue Lu, Yanru Gao, Jintao Niu, Chuang He, Xiaolei Lu   +7 more
doaj   +1 more source