Results 61 to 70 of about 4,327 (216)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Methodological Approach to Assessing Constructability in Building Maintenance and Its Impact on University Quality

Buildings
This study introduces and evaluates an innovative methodology for assessing constructability in the maintenance of university buildings, aiming to improve the quality of academic infrastructure.
Mónica Escate, Doris Esenarro
doaj   +1 more source

Scenarios for Maintenance and Building Decommissioning in the Building’s Life Cycle

IOP Conference Series: Earth and Environmental Science, 2019
The LCC analysis can be applied to assess effectiveness of construction variants or acquisition of new facilities as well as modernization of the existing ones. The authors of this paper intended to apply the LCCA method at analysing a building in the final stage of the building life cycle (grade phase).
E. Plebankiewicz, K. Zima, D. Wieczorek
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Assessment of the Effects of Deferred Maintenance on the Current Technical Condition of a Building: Case Study—A Former Fire Station in Nowy Raduszec

Applied Sciences
The degradation of building elements progresses with the age of a building as a result of natural ageing processes. The lack of regular maintenance, repair, and renovation works during the operational phase accelerates degradation processes, leading to ...
Aleksandra Kurowska-Rajchel, Beata Nowogońska   +1 more
doaj   +1 more source

Building Facade Maintenance

Vestnik Tomskogo gosudarstvennogo arkhitekturno-stroitel'nogo universiteta. JOURNAL of Construction and Architecture
The article is devoted to the problem of providing access to building facades in order to maintain their operational characteristics.Purpose: The purpose of the study is to identify general principles of building facade maintenance that contribute to typification and unification of solutions, and develop practical recommendations for their application ...
L. D. Morshakova, G. A. Bardina, A. I. Zatsepina   +2 more
openaire   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

ANALYSIS OF 5R/S WORK CULTURE IN THE BOWPLANK INSTALLATION PRACTICE IN CONSTRUCTION ENGINEERING

Jurnal Pensil
The installation of bowplanks as part of the assignment work still shows variations due to the less than optimal implementation of the 5R/S work culture in the field, especially in the arrangement of measuring tools, neatness of the work area, and ...
Aulia Putri, Nurul Yuhanafia, Muhammad Nur Fuad   +2 more
doaj   +1 more source

Influence of Climate Conditions on Deficiencies of Building Roofs

Applied Sciences, 2019
Climate conditions affect buildings’ performance and durability. The purpose of this paper is to examine the influence of climate conditions on roof deficiencies. 763 cases of such deficiencies were analyzed in this regard.
Manuel J. Carretero-Ayuso, Alberto Moreno-Cansado, Justo García-Sanz-Calcedo   +2 more
doaj   +1 more source