Results 161 to 170 of about 4,327 (216)
BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity
FEBS Open Bio, EarlyView.Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
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Facilities, 1993
Examines the background to building maintenance management, emphasizing its importance due to new developments in building design. Suggests that, owing to the use of less‐durable materials in construction the need for long‐term planning in order for maintenance to be profitable is important.
exaly +2 more sources
Examines the background to building maintenance management, emphasizing its importance due to new developments in building design. Suggests that, owing to the use of less‐durable materials in construction the need for long‐term planning in order for maintenance to be profitable is important.
exaly +2 more sources
Constantinople: Building and Maintenance
2022It is possible to see the story of Constantinopolitan construction in the city’s first 200 years as a single undertaking. The concentration of political will, economic capacity, and logistic conditions combined to facilitate the influx of the necessary building materials, specialized knowledge, and technological skills from a pan-Mediterranean ...
openaire +3 more sources
Proceedings of the 33rd International Conference on Software Engineering, 2011
The build system, i.e., the infrastructure that converts source code into deliverables, plays a critical role in the development of a software project. For example, developers rely upon the build system to test and run their source code changes. Without a working build system, development progress grinds to a halt, as the source code is rendered ...
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The build system, i.e., the infrastructure that converts source code into deliverables, plays a critical role in the development of a software project. For example, developers rely upon the build system to test and run their source code changes. Without a working build system, development progress grinds to a halt, as the source code is rendered ...
openaire +2 more sources
Property Management, 1988
This item details in note form, aspects of maintenance relevant to the issues of life‐cycle costing discussed in the paper by David Hoar, which was published in the last issue of Property Management.
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This item details in note form, aspects of maintenance relevant to the issues of life‐cycle costing discussed in the paper by David Hoar, which was published in the last issue of Property Management.
openaire +1 more source
Building Maintenance Problems and Their Solution-III
1976This chapter is concerned with building defects that arise from site conditions and inadequate foundations, the various types of temporary works and the maintenance of external works, such as pavings and fences.
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