Results 91 to 100 of about 225,032 (265)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Enhancing Cost Prediction and Estimation Techniques for Sustainable Building Maintenance and Future Development

Encyclopedia
Building maintenance is crucial, yet predicting financial resources for it remains challenging, particularly during the design and construction phases. This research aims to analyze and synthesize existing studies on maintenance cost estimation, with a ...
Dino Obradović, Hana Begić Juričić, Hrvoje Krstić   +2 more
doaj   +1 more source

Building Maintenance Management

, 2021
Buildings are some of the most valuable assets of any nation, in the sense that they provide people shelter, places to work and leisure, and so many others functions. With the rising costs of new buildings, the need for Building Maintenance (BM), has become even more relevant, since it allows the qualification of the built portfolio, helps boosting the
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Synthesis of Multi-Criteria Decision-Making Applications in Facilities Management and Building Maintenance: Trends, Methods, and Future Research Directions

Buildings
Building maintenance decisions are complex and often influenced by various factors. Multi-criteria decision-making (MCDM) methods have been widely applied to address this complexity, yet guidance on selecting the most appropriate method for specific ...
Mahdi Anbari Moghadam, Deniz Besiktepe
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Advantages of using insulation with lower thermal conductivity versus WT 2021 – comparison of the costs of materials, buying and operating a heating device, and a carbon footprint generated

Budownictwo i Architektura
This article presents a comparative analysis of the use of standard insulation material compliant with the current Technical Conditions WT 2021, compared to insulation material with improved thermal conductivity parameters on building partitions.
Patrycja Zawiska
doaj   +1 more source

Design Failure Affecting Maintenance Management on Public Higher Education Institution in Malaysia

MATEC Web of Conferences, 2016
The issue of government building defect is keeping on reporting in the media and arising since 2007. These issues of building defects, maintenance and management have existing and it is deliberated up to the parliament level. The government keep continue
Agus Salim Nuzaihan Aras, Salleh Naziah Muhamad, Zahari Nurul Fadzila   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Design of Structural Damage Identification Applications Web-Based

MATEC Web of Conferences, 2018
The current building construction and maintenance Note well, certainly will be utilized as desired. If a building is experiencing interference, then all activities will be obstructed so that the building requires maintenance activities.
Anisya Anisya, Nugroho Fajar
doaj   +1 more source