Results 111 to 120 of about 8,855,802 (295)

Application of machine learning and numerical simulation for monitoring and early warning systems of landslides and rockfalls in geohazard-prone regions

Frontiers in Earth Science
This paper proposes an integrated framework for ML and numerical simulation-based monitoring and early Warning Systems (EWS) of landslides and rockfalls in geohazard-prone areas.
Zhiqiang Wang, Zhiqiang Wang, Pengfei Jia, Pengfei Jia, Wenhui Liu, Wenhui Liu, Yanbing Yang, Yanbing Yang, Wenlong Wang, Wenlong Wang   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Examining Cardboard as a Construction Material for Sustainable Building Practices in Lima, Peru [PDF]

This research work aimed to analyse the impact and potential of cardboard as a construction material, as well as cultural aspects and sustainable construction regulations, in the context of Lima, Peru.
Taki, A. H., Ahmad Taki, Higa, Daniel Ikemiyashiro, Daniel Ikemiyashiro Higa   +3 more
core   +1 more source

Application of non-degradable waste as building material for low-cost housing. [PDF]

Sci Rep, 2023
Zuraida S, Dewancker B, Margono RB.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Self-assembled silk fibroin cross-linked with genipin supplements microbial carbonate precipitation in building material. [PDF]

Environ Microbiol Rep, 2023
Li J, Achal V.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

External coupling between BES and HAM programs for whole building simulation [PDF]

, 2009
This paper discusses a procedure for the two-way runtime external coupling between Building EnergySimulation (BES) and building envelope Heat, Air and Moisture (HAM) programs for enhanced wholebuilding simulation.
Blocken, B.J.E., Kelly, N.J., Hensen, J.L.M., Costola, D., Strachan, P.A., Kummert, M.   +5 more
core  

Ecotoxicity of Caffeine as a Bio-Protective Component of Flax-Fiber-Reinforced Epoxy-Composite Building Material. [PDF]

Polymers (Basel), 2023
Kobetičová K, Nábělková J, Brejcha V, Böhm M, Jerman M, Brich J, Černý R.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source