Results 111 to 120 of about 592,943 (299)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Integrating Radon/Thoron and Gamma Radiation Exposure for a Realistic Estimation of Dose Arising from Building Materials

open access: yesApplied Sciences
Long-term exposure to radon, thoron, and gamma radiation from building materials poses a significant health risk to occupants. Current methods for estimating radiation doses often fail to consider the combined impact of these sources.
Mirsina M. Aghdam, Quentin Crowley
doaj   +1 more source

Acrylic Resin Filling Cell Lumen Enabled Laminated Poplar Veneer Lumber as Structural Building Material. [PDF]

open access: yesPolymers (Basel), 2022
Gao X   +11 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Building Material: Exploring Playfulness of 3D Printers

open access: yesTransactions of the Digital Games Research Association, 2014
This article explores the practice of 3D printers from a playful perspective. Using the Ultimaker Original as a case study, it addresses the question of whether the practice of open source software and hardware in 3D printing is inherently playful and how the user affects and is affected by its playability.
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

Spent Coffee Grounds as Building Material for Non-Load-Bearing Structures. [PDF]

open access: yesMaterials (Basel), 2022
Moussa T   +10 more
europepmc   +1 more source

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