Results 161 to 170 of about 8,855,802 (295)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Building material price data for predictive cost estimation in construction. [PDF]

Data Brief
Olowe OT, Adebiyi A, Obagbuwa IC.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Visualising a framework for enhancing material circularity in building construction projects: Drivers, barriers, and strategies

Material circularity offers a novel perspective for industrial ecosystems, emphasising the reintegration of materials and products into the supply chain as valuable resources.
Amarasinghe, I, Stewart, RA, Hong, Y
core   +1 more source

Mapping nationwide material stock turnover: High-resolution spatial analysis of building material stock and flow patterns across Japan 2003-2020. [PDF]

J Ind Ecol
Nagata S, Hasegawa M, Fishman T, Shirakawa H, Tanikawa H.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Building material stocks and embodied carbon dataset for two urban agglomerations in China from 2000 to 2020. [PDF]

Sci Data
Liang H, Zhang B, Qian X, Chen Y, Luo Y, Huang Y, Sun L, Zhou C, Long J, Dong L.   +9 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Other title: Kansas State Office Building Commission biennial report, July 1, 1956 to June 30, 1958

, 1958
"December 29, 1958."State Office Building Commission Members -- Letter of Transmittal -- Explanatory Foreword -- Activities During the Biennium -- Recommended Legislation -- Statement of Receipts and Disbursements -- Balance Sheet -- Operation Expenses ...
Kansas. State Office Building Commission.
core  

From Crop Residue to Corrugated Core Sandwich Panels as a Building Material. [PDF]

Materials (Basel)
Lamichhane A, Kuttoor Vasudevan A, Mohammadabadi M, Ragon K, Street J, Seale RD.   +5 more
europepmc   +1 more source