Results 101 to 110 of about 8,702,044 (298)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Utilization of thermal insulating materials based on technical hemp for insulating of building structures

, 2011
Thermal insulating materials provides thermal protection to building structures, lower energy demand for heating and provides in inner environment of buildings thermal comfort in both winter and summer.
Zach, Jiri, Hroudova, Jitka, PETRÁNEK, Vit, Korjenic, Azra   +3 more
core   +4 more sources

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Energetic Performance of Natural Building Materials: Numerical Simulation and Experimental Evaluation

Energies
The current goal of the European Commission, which aims to reduce CO2 by 90% compared to values estimated in 1980, and the ever-increasing sensitivity to environmental sustainability, fully involve the construction sector, which, according to the OECD ...
Costantino Carlo Mastino, Giovanna Concu, Andrea Frattolillo   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Coupled heat and moisture transfer in multi-layer building materials

, 2009
A dynamic mathematical model for simulating the coupled heat and moisture migration through multilayer porous building materials was proposed. Vapor content and temperature were chosen as the principal driving potentials.
Nilsson, Lars-Olof, Qin, Menghao, Aït-Mokhtar, Abdelkarim, Lund University., Belarbi, Rafik, Nilsson, Lars-Olof,   +5 more
core   +1 more source

Effects of temperature, pH and calcium-to-carbonate ratio on the calcium carbonate polymorphs

Discover Civil Engineering
The precipitation of calcium carbonate (CaCO3) polymorphs (calcite, vaterite, and aragonite) plays a crucial role in tailoring the physicochemical properties of construction materials during mineral carbonation.
Mohd Hanifa, Usha Sharma, P. C. Thapliyal, L. P. Singh   +3 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Decreased bio-inhibition of building materials due to transport of biocides

, 2011
Bio-inhibition of buildings and structures is an important issue. In many cases building materials have biocides added to prevent growth of micro-organisms. Growth of microorganisms on building materials has several negative effects; (1) Aesthetic damage,
Mendoza, S.M., Hermanns, S.P.M., Adan, O.C.G., Erich, S.J.F., Floor, W., Homan, W.J.   +5 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source