Results 61 to 70 of about 3,230,333 (209)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Porous materials in building energy technologies—a review of the applications, modelling and experiments [PDF]

, 2018
Improving energy efficiency in buildings is central to achieving the goals set by Paris agreement in 2015, as it reduces the energy consumption and consequently the emission of greenhouse gases without jeopardising human comfort.
Esfahani, Javad Abolfazli, Karimi, Nader, Rashidi, Saman   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Near-Infrared Absorption Enhancement of GaAs Photocathode Through “Sandwich” Micro-Nano Structure

Photonics
In this paper, a nano-layered transmission GaAs photocathode structure is proposed. The near-infrared absorption of the photocathode is enhanced by inserting a “sandwich” structure of nano-SiO2 layer + Si3N4 nanopillar array + nano-SiO2 layer between the
Ziyang Xiao, Miao Dong, Yonggang Huang, Jinhui Yang, Peng Jiao, Pan Shi, Yajie Du, Ying He, Jing Cheng, Yinsheng Xu   +9 more
doaj   +1 more source

Influence of Propagation Distance on Characteristic Parameters of Acoustic Emission Signals in Concrete Materials Based on Low-Frequency Sensor

Advances in Civil Engineering, 2022
Acoustic emission is a nondestructive testing technology based on the propagation of transient elastic waves captured by acoustic emission sensors. The acoustic emission signal depends not only on the distance and quality of the propagation path of the ...
Fen Liu, Rui Guo, Xiujuan Lin, Xiaofang Zhang, Shifeng Huang, Feng Yang, Xin Cheng   +6 more
doaj   +1 more source

The Validation and Discussion of a Comparative Method Based on Experiment to Determine the Effective Thickness of Composite Glass

Buildings
This study introduces and validates a comparative experiment-based method for determining the effective thickness of composite glass, including polymeric laminated glass (with polyvinyl butyral (PVB) and SentryGlas® (SGP) interlayers) and vacuum glazing.
Dake Cao, Xiaogen Liu, Zhe Yang, Jiawei Huang, Ming Xu, Detian Wan   +5 more
doaj   +1 more source

Microbial and metabolic succession on common building materials under high humidity conditions. [PDF]

, 2019
Despite considerable efforts to characterize the microbial ecology of the built environment, the metabolic mechanisms underpinning microbial colonization and successional dynamics remain unclear, particularly at high moisture conditions. Here, we applied
Cardona, Cesar, Gao, Peng, Gilbert, Jack A, Goodney, Gabriel, Gottel, Neil, Hartmann, Erica M, Henry, Chris, Kelley, Scott T, Lax, Simon, Stephens, Brent, Thomas, Paul M, Winton, Valerie J, Zhao, Dan   +12 more
core   +3 more sources

Electrochemistry and capillary condensation theory reveal the mechanism of corrosion in dense porous media

Scientific Reports, 2018
Corrosion in carbonated concrete is an example of corrosion in dense porous media of tremendous socio-economic and scientific relevance. The widespread research endeavors to develop novel, environmentally friendly cements raise questions regarding their ...
Matteo Stefanoni, Ueli M. Angst, Bernhard Elsener   +2 more
doaj   +1 more source