Results 91 to 100 of about 7,009,009 (308)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Reduction methods for the dynamic analysis of substructure models of lighweight building structures [PDF]

, 2014
In the present study, different model order reduction methods were compared in terms of their effects on the dynamic characteristics of individual building components.
Flodén, Ola, Persson, Kent, Sandberg, Göran, Flodén, Ola,, Sandberg, Göran,, Lund University., Persson, Kent,   +6 more
core   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Restoration Study of a Masonry Monumental Building in Thrapsano, Greece

This study investigates structural integrity and proposes retrofitting solutions for the historical two-storey school building in Thrapsano, Crete, severely impacted by the September 2021 earthquake.
Georgios E. Stavroulakis, Maria E. Stavroulaki, Barbara Charalambidi   +2 more
core   +1 more source

Numerical Modeling of Masonry Infilled Reinforced Concrete Building during Construction Stages Using ABAQUS Software

, 2019
The effects of seismic actions on reinforced concrete (RC) structures are strongly influenced by the dynamic behavior of their materials. It is crucial to find a simple definition of the natural frequencies of reinforced concrete buildings, particularly ...
Boudjamaa Roudane, Süleyman Adanur, Ahmet Can Altunışık, Roudane, Boudjamaa, ALTUNIŞIK, AHMET CAN, ADANUR, SÜLEYMAN   +5 more
core   +1 more source

Utilization Possibilities Of Thermal Insulation Plaster For The Rehabilitation Of Problematic Details Of The Building Structures

, 2013
The paper is devoted to the research results in the development of lightweight thermal insulation plaster with lightweight aggregates based on waste glass and using alternative raw materials that constitute metakaolin, finely ground fly ash, blast ...
Zach, Jiri, Hroudova, Jitka, Sedlmajer, Martin, Korjenic, Azra   +3 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Identifying Urban Wood Construction Trends, Global Tall Timber Building Development, and the Role of Wood Promotion Policies

This work studies the presence and evolution of wood construction in urban environments, using Santiago province in Chile as a relevant comparative case.
Felipe Victorero, Waldo Bustamante
core   +1 more source

The Reinforcing Effect of Nano-Modified Epoxy Resin on the Failure Behavior of FRP-Plated RC Structures

, 2023
The ability to manipulate concrete-based and composite materials at the nanoscale represents an innovative approach to improving their mechanical properties and designing high-performance building structures. In this context, a numerical investigation of
Daniele Gaetano, Paolo Nevone Blasi, Paolo Lonetti, Umberto De Maio, Andrea Pranno, Fabrizio Greco   +5 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source