Results 141 to 150 of about 7,009,009 (308)

BUILDING STRUCTURES, METAL STRUCTURES

open access: yes, 2022
Rolled steel is used in the manufacture of building structures such as frames and frames of industrial buildings, farms for various ...
Islomovna, Mamurova Feruza   +1 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Evaluating the response modification factor (R) for reinforced concrete and steel structures equipped with TADAS devices designed for high seismic hazard in Colombia

open access: yes
Colombia is a country with high seismic activity due to its location at the convergence of the Nazca and South American tectonic plates, making structural safety a key priority in the design, construction, and retrofit of buildings. Currently, one of the
Villalba-Morales J.D   +4 more
core   +1 more source

Building Structures Thermal Calculation

open access: yesMaterials Science Forum, 2018
A review of a three-dimensional finite element calculation for a non-stationary heating regime of a compound structure with a complex shape. The accuracy of thermal processes modeling is determined. The temperature fields for the wind power plants blade elements have been determined at the stage of their manufacturing, which made it possible to ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Vibration control of MRE isolator-embedded smart building using genetic algorithm

open access: yes, 2019
This study developed the adaptive genetic algorithm (GA) for vibration control of building structures subjected to ambient hazard excitations. An innovative smart building system was designed based on magnetorheological elastomer (MRE) isolators under ...
Li, Yancheng   +5 more
core  

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