Results 131 to 140 of about 2,125,522 (310)
Investing in Youth Media: A Guide for Grantmakers [PDF]
, 2006 Investing in Youth Media is a compilation of success stories, lessons, and guidance for grantmakers interested in being part of the vibrant and growing field of youth media.
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Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Civil Society Actors as Catalysts for Transnational Social Learning [PDF]
, 2005 This article explores the roles of transnational civil society organizations and networks in transnational social learning. It begins with an investigation into social learning within problem domains and into the ways in which such domain learning builds
L. David Brown, Vanessa Timmer
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Asset Building for Social Change: Pathways to Large-Scale Impact [PDF]
, 2004 Provides an in-depth examination of current and historic initiatives, in an effort to discern patterns of successful scaling up from among Ford's Assets Program portfolios ...
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The effects of team-skills training on transactive memory and performance
, 2007 The existence of effective Transactive Memory Systems (TMS) in teams has been found to enhance task performance. Methods of developing Transactive Memory (TM) are therefore an important focus of research.
Ashleigh, Melanie J., Prichard, Jane S.
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Journal of Lifestyle and SDGs ReviewObjectives: This study aims to analyze and determine the legal certainty of land rights for the Bajo tribe, which lives in the sea waters. In line with Sustainable Development Goals (SDG) 15, which promotes sustainable use of ecosystems and the rights of indigenous communities, this study highlights the importance of securing the Bajo Tribe’s land ...
null Sarni +5 more
openaire +1 more source