Results 51 to 60 of about 130,724 (265)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Building Use Rights Extension Arrangements above Management Rights in Law National Agraria

International Journal of Social Science and Human Research
Land with building use rights over management rights used for public purposes often gives rise to legal problems because the provisions of Article 35 Basic Agrarian Law (BAL) in conjunction with Article 40 of Government Regulation 18/2021 paragraph (2) can be processed subjectively or have multiple interpretations.
I Ketut Suardika,, I Made Suwitra,, I Ketut Kasta Arya Wijaya,   +2 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

USING THE COMBINED LADM-INDOORGML MODEL TO SUPPORT BUIILDING EVACUATION [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2018
During an incident, many people that are located in indoor environments require to follow emergency evacuation procedures. The ‘emergency evacuation’ term has been defined as ‘a critical movement of people from a dangerous area due to the risk or an ...
A. Alattas, A. Alattas, P. van Oosterom, S. Zlatanova, D. Hoeneveld, E. Verbree   +5 more
doaj   +1 more source

Legal Regulations and Implications of Building Use Rights on Land Management Rights for Public Assets

Journal of Law, Politic and Humanities
This article is entitled the regulation and legal implications of building use rights over land management rights for public assets. Using legal research methods with normative research types, using statute research approaches and conceptual approaches .
Jessica Calista, Benny Djaja
openaire   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Acquisition Of Ownership Of Land upon Expiry of Building Use Rights

International Journal Of Humanities Education and Social Sciences (IJHESS)
Land plays a very important role and cannot be separated from human life. Most human activities and needs depend a lot on the soil, since it is the main element that favors survival, both as a place to live and as a space to develop in the social, economic, cultural and political spheres.
Fitriani Abdi, null I Ketut Oka Setiawan
openaire   +1 more source