Results 11 to 20 of about 39,038 (206)
Behaviour and design of composite beams subjected to negative bending and compression [PDF]
, 2012 This paper investigates the behaviour of steel–concrete composite beams subjected to the combined effects of negative bending and axial compression. Six full-scale tests were conducted on composite beams subjected to negative moment while compression was
Kirkland, Brenadan +3 more
core +1 more source
Advances in Building EducationThe historic centre of the city of Cuenca is a UNESCO World Heritage Site and is located in a zone of high seismic hazard. For these reasons, the Urban Development Plan of Cuenca sets out the need to implement measures for the conservation of buildings ...
David Cajamarca-Zuniga +3 more
doaj +1 more source
A geometric characterization of the classical Lie algebras [PDF]
, 2017 A nonzero element x in a Lie algebra g over a field F with Lie product [ , ] is called a extremal element if [x, [x, g]] is contained in Fx. Long root elements in classical Lie algebras are examples of extremal elements. Arjeh Cohen et al.
Cuypers, Hans, Fleischmann, Yael
core +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
A Local-to-Global Result for Topological Spherical Buildings
, 2012 Suppose that \Delta, \Delta' are two buildings each arising from a semisimpe algebraic group over a field, a topological field in the former case, and that for both the buildings the Coxeter diagram has no isolated nodes. We give conditions under which a
McCallum, Rupert
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Regular sequences and random walks in affine buildings [PDF]
, 2014 We define and characterise regular sequences in affine buildings, thereby giving the "$p$-adic analogue" of the fundamental work of Kaimanovich.
Parkinson, James, Woess, Wolfgang
core +3 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Homogeneous compact geometries
, 2014 We classify compact homogeneous geometries of irreducible spherical type and rank at least 2 which admit a transitive action of a compact connected group, up to equivariant 2-coverings.
Kramer, Linus, Lytchak, Alexander
core +1 more source
Diagramming social practice theory:An interdisciplinary experiment exploring practices as networks [PDF]
, 2015 Achieving a transition to a low-carbon energy system is now widely recognised as a key challenge facing humanity. To date, the vast majority of research addressing this challenge has been conducted within the disciplines of science, engineering and ...
Balke T +18 more
core +1 more source