Results 131 to 140 of about 36,570 (264)
Bump detection in heterogeneous Gaussian regression
, 2018 We analyze the effect of a heterogeneous variance on bump detection in a Gaussian regression model. To this end, we allow for a simultaneous bump in the variance and specify its impact on the difficulty to detect the null signal against a single bump ...
Frank Werner +8 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
, 1907 Photograph of Dorothy and Marie Bump on the steps of the Bump Family home, 323 West 10th Street, Oklahoma City, OK, c. 1907-1915.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Astrophysical JournalIn recent years, multiple Type Ia supernovae (SNe Ia) have been observed with “bumps” in their rising light curves shortly after the explosion. Here, we present SN 2021qvo: an SN Ia that exhibits a clear early bump in photometry obtained by the Young ...
I. A. Abreu Paniagua +26 more
doaj +1 more source
Portrait of Clarence L. and Jessie Bump
, 1900 A formal portrait of a young man and woman. He is sitting in a wicker chair and she is standing at his side. Background is a typical studio background.[back] [black printed ink] C. L.
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source