Results 231 to 240 of about 36,570 (264)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Eight-Year Neglected Pediatric Kaplan's MCP Dislocation Following Childhood Trauma Managed by Volar Open Reduction: A Case Report. [PDF]

J Orthop Case Rep
Pol SP, Pawar PP, Sharan S, Joshi A, Ahire PT, Kalal S.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Multimodal cue integration and learning in a neural representation of head direction. [PDF]

Nat Neurosci
Basnak MA, Kutschireiter A, Okubo TS, Chen A, Gorelik P, Drugowitsch J, Wilson RI.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors. [PDF]

Nat Commun
Chakravarty A, Wang LN, Golden RP, Li Z, Donovan KA, Afanzar O, Zhang Y, Fischer ES, Gray NS, Yang PL.   +9 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Haptic-visual evaluation of the J-Sign revealed a significant correlation with patella height, tibial tubercle - trochlear groove distance, trochlear bump height and the total number of risk factors for lateral patellar instability. [PDF]

J Orthop Surg Res
Zimmermann F, Mandelka E, Gierse J, Vetter SY, Grützner PA, Balcarek P.   +5 more
europepmc   +1 more source

Local expansion mechanisms for quantum-scale wormholes. [PDF]

Sci Rep
Dorau P, Much A.
europepmc   +1 more source