Results 201 to 210 of about 1,098,643 (378)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Regional Adherence to Early Sepsis Management Bundle and Associated Mortality in Hong Kong Between 2009-2018. [PDF]

Open Forum Infect Dis
Zhang JZ, Chan CH, Chang LC, Chiu LCS, Ng PY, Dharmangadan M, Ho E, Ling S, Man MY, Fong KM, Liong T, Yeung AWT, Au KF, Chan JKH, Tang M, Li KHK, Wu WKK, Wong WT, Wu P, Cowling BJ, Ho KM, Lee A, Rhee C, Ling L.   +23 more
europepmc   +1 more source

His bundle pacing – a curative method

, 2020
Cătălin Pestrea, Alexandra Gherghina, Florin Orțan, Gabriel Cismaru, Radu Roşu   +4 more
openalex   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Left bundle branch pacing combined with atrioventricular node ablation in atrial fibrillation with severe aortic stenosis: A case report. [PDF]

Medicine (Baltimore)
Zhang S, Nie L, Shao L, Zhang Y, Feng W, Yin Q, Chen Y.   +6 more
europepmc   +1 more source

Impact of a Maternal Early Warning System and Severe Hypertension Safety Bundle on Timely Treatment of Hypertensive Emergencies: A Quality Improvement and Health Equity Initiative [PDF]

Towana D. Sims, Lauren Shubert, Stacie Denning, Lena Shay, Celeste A. Green, Christina M. Davidson   +5 more
openalex   +1 more source

Atrioventricular node ablation and His bundle pacing.

Europace, 2017
P. Vijayaraman, F. Subzposh, Angela M Naperkowski   +2 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Double-bundle anterior cruciate ligament reconstruction (ACLR) and anterolateral ligament reconstruction with suture tape augmentation offers satisfactory 2-year clinical functional scores between single-bundle ACLR and double-bundle ACLR with more lateral knee tightness. [PDF]

BMC Musculoskelet Disord
Hsia L, Chen P, Yang CP, Hsu CH, Chuang CA, Chiu JC.   +5 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source