Results 231 to 240 of about 1,098,643 (378)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Atrioventricular Delay Optimization in His-Optimized Cardiac Resynchronization Therapy: A Case Report. [PDF]

Clin Case Rep
Nguyen Quang M, Kieu Ngoc D, Nguyen Khac Le S, Tran Le Uyen P, Nguyen Tri T.   +4 more
europepmc   +1 more source

Protecting Patients' Electronic Health Records Using Enhanced Active Bundles [PDF]

, 2012
Raed M. Salih, Leszek Lilien, Lotfi Ben Othmane   +2 more
openalex   +1 more source

The preventive surgical site infection bundle in colorectal surgery: an effective approach to surgical site infection reduction and health care cost savings.

JAMA Surgery, 2014
J. Keenan, P. Speicher, J. Thacker, Monica Walter, M. Kuchibhatla, C. Mantyh   +5 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Planar polarized organization of mouse hair cells is established and maintained by STK32A, GPR156 and EMX2. [PDF]

J Cell Sci
Jia S, Goodrich EJ, Tarchini B, Deans MR.   +3 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods. [PDF]

Hum Brain Mapp
Rauland A, Meisler SL, Alexander-Bloch AF, Bagautdinova J, Baller EB, Gur RE, Gur RC, Luo AC, Moore TM, Popovych OV, Reetz K, Roalf DR, Shinohara RT, Sotardi S, Sydnor VJ, Vossough A, Eickhoff SB, Cieslak M, Satterthwaite TD.   +18 more
europepmc   +1 more source

The Fiber Bundle Model: Modeling Failure in Materials

, 2015
A. Hansen, P. C. Hemmer, S. Pradhan
semanticscholar   +1 more source