Results 51 to 60 of about 506,431 (309)
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Journal of Pure and Applied Algebra, 1985 Let K be an algebraically closed field and let \(G=Gr(1,3)\) be the Klein quadric over K. The author uses Bejlinson's ideas [\textit{A. A. Bejlinson}, Funct. Anal. Appl. 12, 214-216 (1979); translation from Funkts. Anal. Prilozh. 12, No.3, 68-69 (1978; Zbl 0402.14006)] to prove that all coherent sheaves on G are built from two bundles by means of ...
openaire +3 more sources
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Transactions of the American Mathematical Society, 1977 A theory of normal bundles for locally knotted codimension two embeddings of PL manifolds is developed. The classifying space for this theory is Cappell and Shaneson’s space B R N 2 BR{N_2} .
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FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source
Bundling in telecommunications [PDF]
, 2008 The paper offers an overview of the literature on bundling in telecommunications sector and its application in the Spanish ...
Begoña Garcéa-Mariñoso +2 more
openaire +2 more sources
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
The Spatial Ventricular Gradient: Intermittent Wolff-Parkinson-White Syndrome, Intermittent Left Bundle Branch Block and Ventricular Premature Contractions [PDF]
, 1956 Mordecai A. Berkun +3 more
openalex +1 more source