Results 61 to 70 of about 817,701 (334)
Circulating histones as clinical biomarkers in critically ill conditions
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Fibre bundle formulation of relativistic quantum mechanics. I. Time-dependent approach
We propose a new fibre bundle formulation of the mathematical base of relativistic quantum mechanics. At the present stage the bundle form of the theory is equivalent to its conventional one, but it admits new types of generalizations in different ...
Bjorken J D +21 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Larry E Miller,1 Melissa S Martinson,2 Joseph S Gondusky,3 Atul F Kamath,4 Friedrich Boettner,5 Samir K Bhattacharyya6 1Miller Scientific Consulting, Inc., Asheville, NC 28803, USA; 2Technomics Research, LLC, Long Lake, MN 55356, USA; 3Department of ...
Miller LE +5 more
doaj
A decomposition theorem for projective manifolds with nef anticanonical bundle [PDF]
Let X be a simply connected projective manifold with nef anticanonical bundle. We prove that X is a product of a rationally connected manifold and a manifold with trivial canonical bundle. As an application we describe the MRC fibration of any projective
Cao, Junyan, Höring, Andreas
core +2 more sources
10 pages, 8 ...
Hans Jörg Limbach +2 more
openaire +2 more sources
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
EULER CHARACTERISTIC OF TANGO BUNDLES
We are interested in a vector bundle constructed by Tango (1976). The Tango bundle is an indecomposable vector bundle of rank \(n-1\) on the complex projective space \(\mathbb{P}^n\).
Hong Cong Nguyen +2 more
doaj +1 more source

