Results 301 to 310 of about 104,116 (405)

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li, Yiying Fan, Shaik Althaf Hussain   +2 more
wiley   +1 more source

Comparative effectiveness of maintenance doses of opioid agonist treatment among individuals with opioid use disorder: a target trial emulation protocol using a population-based observational study. [PDF]

BMJ Open
Zanette M, Min JE, Homayra F, Bach P, Socías ME, Bruneau J, Korthuis PT, Karim E, Seaman S, Bozinoff N, Kennedy MC, Nosyk B.   +11 more
europepmc   +1 more source

GluN2C/D‐containing NMDA receptors enhance temporal summation and increase sound‐evoked and spontaneous firing in the inferior colliculus

The Journal of Physiology, EarlyView.
Abstract figure legend Here, we find that GluN2D‐containing NMDA receptors (NMDARs) are expressed by most vasoactive intestinal peptide neurons in the inferior colliculus (IC). These receptors are less susceptible to Mg2+ blockade compared to GluN2A/B‐containing NMDARs, allowing ions to flow at resting membrane potential.
Audrey C. Drotos, Rachel L. Zarb, Victoria Booth, Michael T. Roberts   +3 more
wiley   +1 more source

Expanding Horizons of Buprenorphine: A Comprehensive Narrative Review of Its Pharmacological Properties and Clinical Applications in Chronic Pain. [PDF]

Pain Ther
Fornasari D, Cuomo A.
europepmc   +1 more source

Buprenorphine: An Analgesic with an Expanding Role in the Treatment of Opioid Addiction

, 2002
Susan Robinson
openalex   +1 more source

Control of action potential afterdepolarizations in the inferior olive by inactivating A‐type currents through KV4 channels

The Journal of Physiology, EarlyView.
Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan, Marion Najac, Indira M. Raman   +2 more
wiley   +1 more source

Hospital-Based Methadone and Buprenorphine Initiation Practices by Addiction Consult Services.

JAMA Netw Open
Cohen SM, Straus E, Fiellin DA, Pomeranz JL, Suzuki J, Tetrault JM, Weimer MB, Edelman EJ, Joudrey PJ.   +8 more
europepmc   +1 more source

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury

The Journal of Physiology, EarlyView.
Abstract figure legend Our study evaluated the therapeutic potential of ErbB2 inhibition (Herceptin) after volumetric muscle loss (VML) injury, primarily evaluating improvements at the neuromuscular junctions (NMJ). A full thickness model of VML injury to the tibialis anterior muscle of adult Lewis rats was used, and treatments included Herceptin, a ...
Jacob R. Sorensen, Daniel B. Hoffman, Christiana J. Raymond‐Pope, Thomas J. Lillquist, Amanda M. Russell, Benjamin T. Corona, Sarah M. Greising   +6 more
wiley   +1 more source

Behavioral Therapy as an Adjunct to Buprenorphine Treatment for Opioid Use Disorder: A Secondary Analysis of 4 Randomized Clinical Trials.

JAMA Netw Open
McHugh RK, Bailey AJ, McConaghy BA, Weiss RD, Fiellin DA, Hillhouse M, Moore BA, Fitzmaurice GM.   +7 more
europepmc   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source