Results 71 to 80 of about 17,243 (263)

A prospective natural history study protocol for clinical trial readiness in synaptic disorders

Epilepsia, EarlyView.
Abstract Objective STXBP1‐related disorder (STXBP1‐RD) and SYNGAP1‐related disorder (SYNGAP1‐RD) are two common genetic synaptopathies that are associated with epilepsy, developmental delay, intellectual developmental disorder, and behavioral problems.
Jillian L. McKee, Sarah M. Ruggiero, Kristin Cunningham, JoeyLynn Coyne, Ian McSalley, Michael C. Kaufman, Bintou Bane, Torrey Chisari, Jonathan Toib, Carlyn Glatts, Sarah Tefft, Julie M. Orlando, Viveknarayanan Padmanabhan, Alexander K. Gonzalez, Alicia Harrison, Charlene Woo, Stephanie A. Zbikowski, Rency Dhaduk, Johanna Mercurio, Macie McCarthy, Jan H. Magielski, Zachary Grinspan, Megan Abbott, Juliet Knowles, Hsiao‐Tuan Chao, Katherine Xiong, Elizabeth Berry‐Kravis, Sepideh Tabarestani, J. Michael Graglia, Kathryn Helde, Virginie McNamar, Charlene Son Rigby, James Goss, Scott Demarest, Andrea Miele, Benjamin Prosser, Michael J. Boland, Samuel R. Pierce, Ingo Helbig   +38 more
wiley   +1 more source

Neural activation during submaximal contractions seems more reflective of neuromuscular ageing than maximal voluntary activation

Frontiers in Aging Neuroscience, 2016
This study aimed at testing the hypothesis that differences in neural activation strategy during submaximal but not maximal plantarflexions exist between young and older men.
Gil eScaglioni, Marco eNarici, Alain eMartin   +2 more
doaj   +1 more source

Sizing and concentration analysis of cfDNA using Biabooster technology: Results from a prospective plasma‐based collection of 77 patients with locally advanced unresectable esophageal cancer

International Journal of Cancer, EarlyView.
What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto, Sophie Gibert, Caroline Delmas, David Tougeron, Amaury Paumier, Alexandre Taillez, Samuel Le Sourd, Delphine Argo Leignel, Philippe Ronchin, Ariane Darut Jouve, Véronique Vendrely, Olivier Riou, Jérôme Martin‐Babau, Thomas Leroy, Laurent Quéro, Naïma Hanoun, Pierre Cordelier, Veronica Pezzella, Jean Pierre Delord, Rosine Guimbaud, Elizabeth Moyal, Catherine Seva   +21 more
wiley   +1 more source

Geochronological reconstruction of the Lateglacial deglaciation in the Arve Valley (Northern French Alps)

Journal of Quaternary Science, EarlyView.
ABSTRACT The timing and spatial patterns of glaciers retreat in the Northern French Alps during the Lateglacial (19.0–11.7 ka) remain debated, reflecting discrepancies among available chronological data sets. The complex interactions between major glaciers, such as the Rhône and Arve glaciers to the north and the Isère glacier to the south, represent a
Quentin Portal, Christian Crouzet, Jean‐François Buoncristiani, Julien Carcaillet   +3 more
wiley   +1 more source

A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation

International Journal of Pediatrics, 2012
The epidemiology of meconium aspiration syndrome (MAS) in term neonates is described in a population-based retrospective study of data recorded for all births from 2000 to 2007 in a French region (Burgundy).
C. Fischer, C. Rybakowski, C. Ferdynus, P. Sagot, J. B. Gouyon   +4 more
doaj   +1 more source

Muscle fatigue in patients with severe long COVID: A 2‐year follow‐up study

PM&R, EarlyView.
Abstract Background Fatigue is recognized as one of the most persistent and debilitating symptoms of long COVID, affecting both functionality and quality of life. However, its long‐term effects, especially beyond the first year after infection, remain poorly understood.
Isabella da Silva Almeida, Leandro Gomes de Jesus Ferreira, Marco Aurélio Vaz, Rochelle Rocha Costa, Nicolas Babault, Rita de Cássia Marqueti, João Luiz Quagliotti Durigan   +6 more
wiley   +1 more source

Weeds in a changing climate: Competitors or service plants?

PLANTS, PEOPLE, PLANET, EarlyView.
Reducing herbicide use and preparing agroecosystems for climate change are two top priorities on the global policy agenda. Here, we explore whether these two challenges can be tackled simultaneously. While weeds are generally considered a threat to crop production, we show that weeds can help overcome climate change challenges in agroecosystems ...
Marie J. Zwetsloot, Marie‐Charlotte Bopp, Lammert Bastiaans, Elena Kazakou, Aurélie Metay, Gabriel Y. K. Moinet, Karim Barkaoui, Guillaume Fried, Léo Garcia, Merel Hofmeijer, Martine van der Ploeg, Maria Stefania Przybylska, Gerlinde B. De Deyn   +12 more
wiley   +1 more source

Accelerating the prioritisation of plant species with underexplored medicinal potential: The pm4mp (Phylogenetic Methods for Medicinal Plants) R package

PLANTS, PEOPLE, PLANET, EarlyView.
Medicinal plants used in ethnobotanical traditions to treat or prevent diseases have gained renewed interest for their largely untapped potential in drug discovery. In this study, we developed and tested novel methods to prioritise plant species based on their unexplored medicinal potential. By enabling researchers to target the most promising species,
Giovanni Zecca, Elisa Toini, Massimo Labra, Fabrizio Grassi   +3 more
wiley   +1 more source

Oestrus ovis external ophtalmomyiasis: a case report in Burgundy France

BMC Ophthalmology, 2018
Background External ophtalmomyiasis (EOM) is a zoonosis related to the presence of Oestrus ovis larvae at the ocular level in small ruminants (i.e. ovine, caprine).
Louise Basmaciyan, Pierre-Henry Gabrielle, Stéphane Valot, Marc Sautour, Jean-Christophe Buisson, Catherine Creuzot-Garcher, Frédéric Dalle   +6 more
doaj   +1 more source

Assessing the Performance of European Union Regions in the “People” and “Prosperity” Pillars of the SDGs

Sustainable Development, EarlyView.
ABSTRACT This paper addresses the gap in subnational assessments of Sustainable Development Goals (SDGs) by benchmarking the performance of European Union NUTS‐2 regions in the People and Prosperity pillars of the 2030 Agenda for Sustainable Development.
Pablo Arocena, Pedro Pascual, Margarita Vega   +2 more
wiley   +1 more source