Results 51 to 60 of about 38,497 (260)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Controversial Funerary Art in British Empire War Cemeteries (1917-1922)
Miranda: Revue Pluridisciplinaire du Monde AnglophoneCemeteries are places of remembrance and meditation, but also spaces for artistic expression. The shape of funerary monuments can be defined by the deceased themselves before their death or by their relatives after their death, and reflect their life and
Raphaël Willay
doaj +1 more source
Revue des Mondes Musulmans et de la Méditerranée, 2018 Our proposal questions, through socio-anthropological and empirical reflection, the public management of "the death of the emigrant" in the two communities of belonging to the emigre: the country of immigration (Saint-Étienne) and the village of origin ...
Azzedine Kinzi
doaj +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Petroleum geology of the Upper Jurassic – Lower Cretaceous of East and North-East Greenland: Blokelv-1 borehole, Jameson Land Basin: Burial and exhumation history of the Jameson Land Basin, East Greenland, estimated from thermochronological data from the Blokelv-1 core (including Appendix) [PDF]
Geological Survey of Denmark and Greenland Bulletin, 2018 Apatite fission-track analysis (AFTA) data in two Upper Jurassic core samples from the 231 m deep Blokelv-1 borehole, Jameson Land, East Greenland, combined with vitrinite reflectance data and regional AFTA data, define three palaeo-thermal episodes.
Paul F. Green, Peter Japsen
doaj
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The memorable service and monastic humility – the history of Stanisław Konarski’s heart
Folia Historica Cracoviensia, 2016 The article concentrates on an interesting 130-year-old artefact located in the Krakow church of Piarists – the decoration of the place where Stanisław Konarski’s (1700–1773) heart was buried. Konarski was a monk of the Pious Schools in the 18th century,
Ryszard Mączyński
doaj +1 more source