Results 1 to 10 of about 2,588 (258)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

On the edge of the eurasian steppes: the sarmatian culture in the 1st–3rd centuries ad east of the Carpathians

Поволжская археология
The paper analyses the Sarmatian culture east of the Carpathians during the 1st-3rd centuries AD, shedding light on their burial practices, artefacts, and socio-economic interactions.
Grumeza Lavinia, Cojocaru Victor
doaj   +1 more source

The Early Bronze Age grave from the site of Svinjarička čuka, South-Eastern Serbia: New data on burial customs and cultural interactions of the early bronze age in the Central Balkans [PDF]

Starinar
During the excavations of the multi-layered prehistoric site of Svinjarička Čuka in south-eastern Serbia, a single burial was recorded. According to the grave goods, the burial custom, and an absolute date, the burial can be positioned into the ...
Bulatović Aleksandar, Pernicka Ernst, Mladenović Ognjen, Waltenberger Lukas, Horejs Barbara   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Kurgan 28 of the Filippovka 1 Burial Ground: Revisiting the Dating Problem of the Complex

Нижневолжский археологический вестник, 2023
The papre is devoted to determining the date of the kurgan 28, Filippovka 1 burial ground, which is a necropolis of the social elite of the Southern Urals nomads in the middle of the 1st millennium BC. A burial partially destroyed by repeated robbery was
Olga V. Anikeeva, Vladimir N. Myshkin
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Andronovites in the Eastern Pamirs: on the Issue of Dating and Origins of the Xiabandi AII Cemetery in Xinjiang (China) [PDF]

Вестник археологии, антропологии и этнографии
This study examines the Bronze Age period in the Eastern Pamirs using materials from the cemetery of Xiabandi AII, through the analysis of its burial practices and grave goods, and planigraphy of the site.
Shi Handa
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source