Results 31 to 40 of about 10,379 (254)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Eneolithic Burial of Maksimovka I Soil Burial Ground from the Samara Trans-Volga Region

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2019
Introduction. In the early 1980s the materials of soil burial grounds served as a base for identifying a special Eneolithic period in the history of the Middle and Lower Volga regions.
Victor A. Tsibin, Anton A. Shalapinin
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Osteological Complexes of the Late Bronze Age Uranbash Burial Ground in the Orenburg Region

Археология евразийских степей
This article presents the results of archaeozoological study of osteological complexes from the Uranbash burial ground (Uranbash-yuzhniy), located in the Oktyabrskoye district of the Orenburg region.
Natalya V. Roslyakova , Irina M. Grigorieva   +1 more
doaj   +1 more source

Hooked Clasps from Tarasovo Burial Ground

Поволжская археология, 2018
The paper features an analysis of hooked clasps (HC) from Tarasovo burial ground located in the Middle Kama region (134 items from 81 graves). The HC are designed for fastening belts with a hook and a loop used in clothing (headwear, belts and shoes) and
Goldina Rimma D.
doaj   +1 more source

Boy Hunter Burial from Staroe Kirgizovo Burial Ground of the Pyany Bor Culture

Поволжская археология, 2021
The paper presents the materials from burial No. 53 of the Staroe Kirgizovo burial ground of the Pyany Bor culture from the territory of the Ik and Belaya interfluve (excavations of 2016).
Zubov Sergey E. , Liphanov Nikolay A. , Roslyakova Natalya V., Sattarov Ruzil R.   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Burial Mound 7 of Sara Burial Ground (D.I. Zakharov’s Excavations, 1928): Historiographic Research

Нижневолжский археологический вестник, 2019
The article is devoted to historiographic research of the excavation materials from mound 7 of Sara burial ground. The excavations took place in the Eastern Orenburg area in 1928.
Vitaliy K. Fedorov
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source