Results 141 to 150 of about 7,006 (219)

Histological and metagenomic analysis of microbial communities in archaeological human bones. [PDF]

PLoS One
Kaptan D, Flemming Elvers AC, Kjær Knudsen A, Schroeder H, Hollund HI.   +4 more
europepmc   +1 more source

Stage‐Specific Patterns of Imaging and Non‐Motor Biomarkers in Spinocerebellar Ataxia Type 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Advancements in disease‐modifying therapies for spinocerebellar ataxia Type 3 (SCA3) underscore the need for robust biomarkers to monitor disease progression and evaluate treatment efficacy. Although motor phenotypes have been well characterized, less is known about non‐motor and imaging‐based features across different disease stages.
Chun Li, Zhi‐Xian Ye, Xuan‐Yu Chen, Liang‐Liang Qiu, Zhi‐li Chen, Yu‐Sen Qiu, Wei Lin, Ru‐Ying Yuan, Xin‐Tong Yu, Chun‐Yu Huang, Xin‐Yuan Chen, Min‐Ting Lin, Jian‐Ping Hu, Wan‐Jin Chen, Ning Wang, Shao‐Bo Yao, Shi‐Rui Gan, Ying Fu   +17 more
wiley   +1 more source

A refined phylochronology of the second plague pandemic in Western Eurasia. [PDF]

Proc Natl Acad Sci U S A
Keller M, Guellil M, Slavin P, Saag L, Irdt K, Kabral H, Solnik A, Malve M, Valk H, Kriiska A, Cessford C, Inskip SA, Robb JE, Cooper C, von Planta C, Seifert M, Reitmaier T, Baetsen WA, Walker D, Lösch S, Szidat S, Metspalu M, Kivisild T, Tambets K, Scheib CL.   +24 more
europepmc   +1 more source

Myostatin/Smad3 in Spinal Muscular Atrophy: Biomarkers of Disease Severity and Treatment Response

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Given the role of Myostatin (MSTN) in muscle homeostasis and its modulation by current spinal muscular atrophy (SMA) therapies, we investigated serum MSTN and, for the first time, its downstream effector Smad3 as candidate non‐invasive biomarkers in SMA patients undergoing disease‐modifying therapies (DMTs).
Giorgia Riolo, Claudia Dosi, Stefano Parravicini, Riccardo Zanin, Marta Cheli, Eleonora Giacopuzzi Grigoli, Amalia Canciello, Francesca Andreetta, Riccardo Masson, Silvia Bonanno, Stefania Marcuzzo, Lorenzo Maggi   +11 more
wiley   +1 more source

Skeletons in the permafrost: Exploring climate-driven heritage loss and occupational health at the early modern whaling burial site of Likneset, Svalbard. [PDF]

PLoS One
Loktu L, Brødholt ET.
europepmc   +1 more source

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Bioarchaeological evidence of mycoses during the Late Antiquity-Early Middle Ages transition in Central Italy. [PDF]

Sci Rep
Buzi C, Merola A, Messineo D, Ostrosky-Zeichner L, Paine RR, Manzi G, Smith DJ, Micarelli I.   +7 more
europepmc   +1 more source

The association of gout flare resolution with physical activity and sleep: a prospective remote‐monitoring study

Arthritis Care &Research, Accepted Article.
Objectives This study aimed to determine whether gout flare resolution is associated with physical activity and sleep. These findings were intended to inform the future development of a definition for flare resolution. Methods Data from 81 participants with gout who experienced >1 flare during a 6‐month prospective observational study were included ...
Sarah Stewart, Boston Girven, Mia Clarke, Irene Zeng, Angelo Gaffo, Lisa K Stamp, N Lawrence Edwards, David Rice, Tania Ka'ai, Karl Rudolph, Julie Collis, Nicola Kayes, Nicola Dalbeth   +12 more
wiley   +1 more source

Notes from the Field: Characteristics and Monitoring of the 2026 Outbreak of Ebola Disease Caused by Bundibugyo Virus - Democratic Republic of the Congo, August 2026. [PDF]

MMWR Morb Mortal Wkly Rep
Kabasele D, Meyer E, Kabore I, Dismer A, Kabamba JK, Bratcher A, Kola CK, Eggers C, Zomahoun D, Hall N, Ekwanzala MD, Peters N, Schuh A, Sealy T, Ricks P, Mutombo BM, Kinzer M, Dahl BA, Kabore H, Choi MJ, Rossow J, Ellington S, CDC 2026 Ebola Response International Epidemiology and Laboratory Task Force.   +22 more
europepmc   +1 more source