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Accelerated Adaptive Evolution of Gram‐Negative Bacteria With a Broad‐Host‐Range Dual Base Editor
We developed a broad‐host‐range dual base editor that transiently induces genome‐wide hypermutation, accelerating adaptive laboratory evolution by up to four orders of magnitude. The platform rapidly generates improved bacterial phenotypes across diverse Gram‐negative species, enabling faster evolutionary engineering for biotechnology.
Tomas Aparicio +4 more
wiley +1 more source
Objective To report 45 cases of melioidosis in dogs and cats from northern Australia and analyse trends in epidemiology, clinical presentation, pathogenesis and response to treatment over a 27‐year period. Design Retrospective and prospective analysis of clinical records.
K Lee +6 more
wiley +1 more source
Source identified and case definition established: multistate investigation of non-travel associated Burkholderia pseudomallei infections (melioidosis) in four patients: Georgia, Kansas, Minnesota, and Texas \u2013 2021 [PDF]
cdc:110991Distributed via the CDC Health Alert NetworkNovember 03, 2021, 11:00 AM ETCDCHAN-00456Whole genome sequencing (WGS) at the Centers for Disease Control and Prevention (CDC) confirmed that the strain of Burkholderia pseudomallei in bottles of ...
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Summary Arbuscular mycorrhizal fungi (AMF) are widespread plant symbionts that enhance nutrient acquisition and influence ecosystem productivity. Previous chromosome‐level assemblies of the model species Rhizophagus irregularis revealed a two‐compartment genome architecture (active A and repressed B chromatin compartments), yet its conservation across ...
Ken Mugambi +10 more
wiley +1 more source
Synthetic community complexity reduction designs. Summary Plant growth is influenced by the composition of its associated microbiome. The inherent complexity and functional redundancy of natural plant microbiomes present a formidable barrier to understanding the myriad biological interactions therein.
Dean Pettinga +8 more
wiley +1 more source
Burkholderia pseudomallei Infections [PDF]
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Immunology & Cell Biology, 2014
Autophagy has become increasingly viewed as an important component of the eukaryotic innate immune system. The elimination of intracellular pathogens by autophagy in mammalian cells (xenophagy) results not only in the degradation of invading bacteria, viruses, fungi and parasites, but also liberation of metabolites that may have been utilized during ...
Rodney J Devenish, Shu‐chin Lai
openaire +2 more sources
Autophagy has become increasingly viewed as an important component of the eukaryotic innate immune system. The elimination of intracellular pathogens by autophagy in mammalian cells (xenophagy) results not only in the degradation of invading bacteria, viruses, fungi and parasites, but also liberation of metabolites that may have been utilized during ...
Rodney J Devenish, Shu‐chin Lai
openaire +2 more sources

