Results 31 to 40 of about 2,172,661 (342)

Allogeneic mesenchymal stem cells for treatment of severe burn injury

Stem cell research & therapeutics, 2019
The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries.
M. Jeschke, S. Rehou, M. McCann, Shahriar Shahrokhi   +3 more
semanticscholar   +1 more source

Weakened IL-15 Production and Impaired mTOR Activation Alter Dendritic Epidermal T Cell Homeostasis in Diabetic Mice

Scientific Reports, 2017
Diabetes is associated with impaired wound healing, which may be caused primarily by a deficiency in dendritic epidermal T cells (DETCs). In the epidermis, IL-15, IGF-1, and mTOR are known to regulate the maintenance of DETCs; however, it is unclear how ...
Zhongyang Liu, Guangping Liang, Li Gui, Yashu Li, Meixi Liu, Yang bai, Xiaorong Zhang, Xiaohong Hu, Jian Chen, Chibing Huang, Xusheng Liu, Gaoxing Luo, Jun Wu, Weifeng He   +13 more
doaj   +1 more source

Hypoxia induces alterations in tRNA modifications involved in translational control

BMC Biology, 2023
Background Adaptation to high-altitude hypobaric hypoxia has been shown to require a set of physiological traits enabled by an associated set of genetic modifications, as well as transcriptome regulation.
Huanping Guo, Lin Xia, Wei Wang, Wei Xu, Xipeng Shen, Xiao Wu, Tong He, Xuelin Jiang, Yinying Xu, Pan Zhao, Dongmei Tan, Xi Zhang, Yunfang Zhang   +12 more
doaj   +1 more source

Facing challenges with hope: universal immune cells for hematologic malignancies

Cancer Biology & Medicine, 2023
Many patients have achieved a favorable overall survival rate since allogenic hematopoietic stem cell transplantation (allo-HSCT) has been widely implemented to treat hematologic malignancies.
Yuqing Wang, Ruihao Huang, Zheng Wang, Jingkang Xiong, Xiaoqi Wang, Xi Zhang   +5 more
doaj   +1 more source

Social Complexity and Risk for Pediatric Burn Injury: A Systematic Review.

Journal of Burn Care & Research, 2019
Social complexity in health outcomes has been attributed to greater risk of injury, adverse health consequences, and early death in a variety of populations.
A. Padalko, N. Cristall, J. Gawaziuk, S. Logsetty   +3 more
semanticscholar   +1 more source

iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53

PLoS ONE, 2017
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting.
Harumasa Nakazawa, Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Shohei Shinozaki, Takashi Yasukawa, Takashi Yasukawa, Kazuhiro Ishimaru, Kazuhiro Ishimaru, S. Yasuhara, S. Yasuhara, Yong-Ming Yu, Yong-Ming Yu, J. Martyn, J. Martyn, Ronald G. Tompkins, Ronald G. Tompkins, K. Shimokado, M. Kaneki, M. Kaneki   +19 more
semanticscholar   +1 more source

Expert consensus on the evaluation and diagnosis of combat injuries of the Chinese People’s Liberation Army

Military Medical Research, 2018
The accurate assessment and diagnosis of combat injuries are the basis for triage and treatment of combat casualties. A consensus on the assessment and diagnosis of combat injuries was made and discussed at the second annual meeting of the Professional ...
Zhao-wen Zong, Lian-yang Zhang, Hao Qin, Si-xu Chen, Lin Zhang, Lei Yang, Xiao-xue Li, Quan-wei Bao, Dao-cheng Liu, Si-hao He, Yue Shen, Rong Zhang, Yu-feng Zhao, Xiao-zheng Zhong, representing the PLA Professional Committee and Youth Committee on Disaster Medicine   +14 more
doaj   +1 more source

HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

Journal of Experimental & Clinical Cancer Research, 2020
Background Emerging evidence suggests that epithelial mesenchymal transition (EMT) and epigenetic mechanisms promote metastasis. Histone deacetylases (HDACs) and noncoding RNAs (ncRNAs) are important epigenetic regulators.
Xue-ting Hu, Wei Xing, Rong-sen Zhao, Yan Tan, Xiao-feng Wu, Luo-quan Ao, Zhan Li, Meng-wei Yao, Mu Yuan, Wei Guo, Shang-ze Li, Jian Yu, Xiang Ao, Xiang Xu   +13 more
doaj   +1 more source

A retrospective cohort study to compare post-injury admissions for infectious diseases in burn patients, non-burn trauma patients and uninjured people

Burns & Trauma, 2018
Background Injury triggers a range of systemic effects including inflammation and immune responses. This study aimed to compare infectious disease admissions after burn and other types of injury using linked hospital admissions data.
Janine M. Duke, Sean M. Randall, James H. Boyd, Mark W. Fear, Suzanne Rea, Fiona M. Wood   +5 more
doaj   +1 more source

Development of a personalized visualization and analysis tool to improve clinical care in complex multisystem diseases with application to scleroderma

Arthritis Care &Research, Accepted Article.
Background In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of a scleroderma patient's ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source