Results 31 to 40 of about 2,417,990 (393)

METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer

open access: yesMolecular Cancer, 2022
Background Continual expression of PD-L1 in tumor cells is critical for tumor immune escape and host T cell exhaustion, however, knowledge on its clinical benefits through inhibition is limited in breast cancer.
Weijun Wan   +13 more
doaj   +1 more source

Intestinal barrier dysfunction in severe burn injury

open access: yesBurns & Trauma, 2019
Severe burn injury is often accompanied by intestinal barrier dysfunction, which is closely associated with post-burn shock, bacterial translocation, systemic inflammatory response syndrome, hypercatabolism, sepsis, multiple organ dysfunction syndrome ...
Wen He, Yu Wang, Pei Wang, Feng-jun Wang
semanticscholar   +1 more source

Reconstruction and Functional Annotation of P311 Protein–Protein Interaction Network Reveals Its New Functions

open access: yesFrontiers in Genetics, 2019
P311 is a highly conserved multifunctional protein. However, it does not belong to any established family of proteins, and its biological function has not been entirely determined.
Song Wang   +10 more
doaj   +1 more source

Anti‐inflammatory hydrogel dressings and skin wound healing

open access: yesClinical and Translational Medicine, 2022
Hydrogels are promising and widely utilized in the biomedical field. In recent years, the anti‐inflammatory function of hydrogel dressings has been significantly improved, addressing many clinical challenges presented in ongoing endeavours to promote ...
Can Huang   +8 more
doaj   +1 more source

The Cutaneous Inflammatory Response to Thermal Burn Injury in a Murine Model

open access: yesInternational Journal of Molecular Sciences, 2019
Many burn interventions aim to target the inflammatory response as a means of enhancing healing or limiting hypertrophic scarring. Murine models of human burns have been developed, but the inflammatory response to injury in these models has not been well
Zabeen Lateef   +5 more
semanticscholar   +1 more source

Allogeneic mesenchymal stem cells for treatment of severe burn injury

open access: yesStem cell research & therapeutics, 2019
The most important determinant of survival post-burn injury is wound healing. For decades, allogeneic mesenchymal stem cells (MSCs) have been suggested as a potential treatment for severe burn injuries.
M. Jeschke   +3 more
semanticscholar   +1 more source

Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis

open access: yesCritical Care, 2020
BackgroundAcute kidney injury (AKI) is a common complication in burn patients admitted to the intensive care unit (ICU) associated with increased morbidity and mortality.
Torgeir Folkestad   +6 more
semanticscholar   +1 more source

Weakened IL-15 Production and Impaired mTOR Activation Alter Dendritic Epidermal T Cell Homeostasis in Diabetic Mice

open access: yesScientific Reports, 2017
Diabetes is associated with impaired wound healing, which may be caused primarily by a deficiency in dendritic epidermal T cells (DETCs). In the epidermis, IL-15, IGF-1, and mTOR are known to regulate the maintenance of DETCs; however, it is unclear how ...
Zhongyang Liu   +13 more
doaj   +1 more source

A Review of Adjunctive Therapies for Burn Injury Pain during the Opioid Crisis.

open access: yesJournal of Burn Care & Research, 2019
Opioids are the mainstay of pain management after burn injury. The United States currently faces an epidemic of opioid overuse and abuse, while simultaneously experiencing a nationwide shortage of intravenous narcotics.
Daniel E Kim   +5 more
semanticscholar   +1 more source

The Long-Term Impact of Physical and Emotional Trauma: The Station Nightclub Fire [PDF]

open access: yes, 2012
Background: Survivors of physical and emotional trauma experience enduring occupational, psychological and quality of life impairments. Examining survivors from a large fire provides a unique opportunity to distinguish the impact of physical and ...
Fregni, Felipe   +6 more
core   +6 more sources

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