Results 21 to 30 of about 280,486 (313)

77 METHODS FOR IDENTIFYING FILIPINO GENDER MINORITIES AND MENTAL HEALTH RISKS IN ELECTRONIC HEALTH RECORDS

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: Aim 1: To explore methodologies to identify gender minorities, and Filipinos, separately, in an electronic health record system. Aim 2: To characterize the similarities and differences in demographic, socioeconomic, and mental health of
Charlene Bumanglag, Stephanie Mikhail, Renee Rumler, James Davis, Deborah Goebert   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns

Frontiers in Immunology
BackgroundSevere burns can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) due to inflammation-immunity dysregulation. This study aimed to identify key immune-related molecules and potential drugs for
Yang Xiang, Bo-han Pan, Jin Zhang, Ji-qiu Chen, He Fang, Qun Wang, Lin-hui Li, Tian-sheng Chen, Jia-xin Chen, Jia-xin Chen, Chan Li, Xing-feng Zheng, Shi-hui Zhu   +12 more
doaj   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Burns

Current Opinion in Anaesthesiology, 1998
Inhalation injuries still significantly increase the morbidity and mortality of burn patients. Advances in ventilatory support appear to decrease the frequency of pneumonia and improve the survival of patients. It is now well accepted that early enteral feeding of patients with burn injuries is very important.
P, Carl, H, Reich
openaire   +4 more sources

Clinicoepidemiological profile of thermal burn injuries and its mortality risk factors in a tertiary care center in Uttarakhand

Indian Journal of Burns, 2021
Introduction: Burns are a major burden to the society in terms of lives lost, treatment costs, and postburn deformities. This study aims to identify the incidence, causes of burns, associated risk factors, and mortality in a tertiary care center in ...
Pankaj Kumar Verma, Himanshu Saxena, Sriranjan Kala, Mohit Singh, Komal Tripathi   +4 more
doaj   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Myristoylated Cathelicidin-DM Fused With ANG1-7: A Novel Self-Assembling Antimicrobial Peptide for the Treatment and Mechanism of Diabetic Infected Wounds

Journal of Diabetes Research
Diabetic wounds, due to severe vascular dysfunction, persistent inflammatory responses, and susceptibility to microbial infections, exhibit delayed healing and pose a significant challenge to human health.
Rongqin Feng, Peng Wang, Li Fan, He Lu, Danna Yao, Panpan Sun, Zhonghua Liu, Fu Han, Xiaozhi Bai, Xuekang Yang, Juntao Han   +10 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications

Journal of Nanobiotechnology
Wound healing outcomes critically depend on precise regulation of oxidative and antimicrobial microenvironments. Traditional dressings have limited wound responsiveness, insufficient infection control, and limited treatment accuracy.
Xiaoyang Liu, Huihui Zhang, Lianglong Chen, Zesen Zheng, Wenwen Li, Chaoyang Huang, Hai Zhou, Yanqi Chen, Ziwei Jiang, Jiaqi Liang, Qiuyi Yu, Lei Yang   +11 more
doaj   +1 more source