Results 171 to 180 of about 59,148 (256)

A Comparison of the Application of Four MEA-Based Neurotoxicity Screening Methods in Ni²⁺ Neurotoxicity Assessment. [PDF]

Toxics
Meng C, Lu Y, Huang Y, Wang ZG, Lü XY.
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Enhancing colonic anastomotic healing with a novel melatonin-loaded PLGA matrix. [PDF]

Exp Physiol
Demir U, Yurtgezen ZG, Erbil G, Gökçe ON, Oral A, Uzun M.   +5 more
europepmc   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Biophysically inspired mean-field model of neuronal populations driven by ion-exchange mechanisms. [PDF]

Elife
Rabuffo G, Bandyopadhyay A, Calabrese C, Gudibanda K, Depannemaecker D, Takarabe LM, Chatterjee S, Saggio ML, Desroches M, Ivanov A, Linne ML, Bernard C, Petkoski S, Jirsa V.   +13 more
europepmc   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source

NbOx Mott Memristor‐Based Oscillatory P‐trit for Ternary Potts Machine

Advanced Science, EarlyView.
A ternary Potts machine utilizing NbOx‐based probabilistic trits (p‐trits) is demonstrated for efficient combinatorial optimization. By leveraging the electro‐thermal switching dynamics of NbOx memristors, this architecture generates three‐state stochastic fluctuations.
Hakseung Rhee, Seoeun Jang, Tae Wook Go, Woojoon Park, Gwangmin Kim, Do Hoon Kim, Hanchan Song, Younghyun Lee, Junmo Kang, Daehee Kim, Kyung Min Kim   +10 more
wiley   +1 more source

Third trimester-equivalent alcohol exposure reduces neurons in males and increases Vglut2⁺ neurons with reduced intrinsic bursting in females in the murine dorsal subiculum. [PDF]

Neuropharmacology
Lopez KM, Choi H, Feng A, Cazares L, Roman JK, Chavez GJ, Garcia MM, Jaramillo J, Valenzuela CF.   +8 more
europepmc   +1 more source

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

Higher-order thalamic bursts are drivers of attention control. [PDF]

Neuron
Boshra R, Harris M, Dougherty K, Berg M, Morea BM, Alitto HJ, Rodriguez MC, Usrey WM, Kastner S.   +8 more
europepmc   +1 more source