Results 101 to 110 of about 59,242 (303)

Estrogen‐dependent control and cell‐to‐cell variability of transcriptional bursting

Molecular Systems Biology, 2018
Cellular decision‐making and environmental adaptation are dependent upon a heterogeneous response of gene expression to external cues. Heterogeneity arises in transcription from random switching between transcriptionally active and inactive states ...
Christoph Fritzsch, Stephan Baumgärtner, Monika Kuban, Daria Steinshorn, George Reid, Stefan Legewie   +5 more
doaj   +1 more source

Emergent bursting and synchrony in computer simulations of neuronal cultures

Frontiers in Computational Neuroscience, 2012
Experimental studies of neuronal cultures have revealed a wide variety of spiking network activity ranging from sparse, asynchronous firing to distinct, network-wide synchronous bursting.
Niru eMaheswaranathan, Silvia eFerrari, Antonius M J VanDongen, Craig eHenriquez   +3 more
doaj   +1 more source

On vortex bursting [PDF]

, 1984
Vortex bursting is studied by means of visualization. The physical behavior of the phenomenon is emphasized, and its similarity with boundary layer separation or wake bursting becomes apparent.
Werle, H.
core  

Optimal Control Drives Ultrafast and Energy‐Efficient Magnetization Switching in Van der Waals Magnets

Advanced Materials, EarlyView.
ABSTRACT The accelerating expansion of data‐centric technologies is sharply increasing the energy burden of information storage, placing unprecedented pressure on the efficiency of magnetic switching. Conventional field‐driven reversal, once the foundation of magnetic memory, has become impractical in modern architectures due to its high energy cost ...
Mohammad H. Badarneh, PeiYu Cai, Elton J. G. Santos   +2 more
wiley   +1 more source

Nano‐Architected Metallic Metamaterial With Enhanced Fatigue Resistance via Dislocation Starvation

Advanced Materials, EarlyView.
Nanoscale Ni single crystals exhibit remarkable fatigue resistance over an order of magnitude higher than that of bulk single crystals through dislocation starvation. By translating this mechanism into geometric nano‐architecture, nano‐architected Ni single‐crystal metamaterials achieve about twice the fatigue resistance of the bulk, despite their ...
Kota Sugisaka, Yamato Ishizaka, Hiroki Ikeda, Shigeo Arai, Masataka Abe, Yoshitaka Umeno, Hiroyuki Shima, Takashi Sumigawa   +7 more
wiley   +1 more source

Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network

Mathematical models of gene regulatory networks are widely used to study cell fate changes and transcriptional regulation. When designing such models, it is important to accurately account for sources of stochasticity.
Galla, Tobias, Kursawe, Jochen, Moneyron, Antoine   +2 more
core   +1 more source

Transcriptional Bursting and Co-Bursting Regulation by Steroid Hormone Release Pattern and Transcription Factor Mobility

, 2019
Genes are transcribed in a discontinuous pattern referred to as RNA bursting, but the mechanisms regulating this process are unclear. Although many physiological signals, including glucocorticoid hormones, are pulsatile, the effects of transient ...
Ferguson, Matthew L., Huynh, Anh
core   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Modeling Excitable Cells with Memristors

Journal of Low Power Electronics and Applications
This paper presents an in-depth analysis of an excitable membrane of a biological system by proposing a novel approach that the cells of the excitable membrane can be modeled as the networks of memristors.
Maheshwar Sah, Alon Ascoli, Ronald Tetzlaff, Vetriveeran Rajamani, Ram Kaji Budhathoki   +4 more
doaj   +1 more source

Optogenetic activation of nigral inhibitory inputs to motor thalamus in the mouse reveals classic inhibition with little potential for rebound activation

Frontiers in Cellular Neuroscience, 2014
The inhibitory output from the internal pallidum and substantia nigra to the thalamus forms an important link in the transmission of basal ganglia processing to cortex.
Jeremy R Edgerton, Jeremy R Edgerton, Dieter eJaeger   +2 more
doaj   +1 more source