Results 61 to 70 of about 59,149 (303)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Biophysical modulation and robustness of itinerant complexity in neuronal networks

open access: yesFrontiers in Network Physiology
Transient synchronization of bursting activity in neuronal networks, which occurs in patterns of metastable itinerant phase relationships between neurons, is a notable feature of network dynamics observed in vivo.
Siva Venkadesh   +6 more
doaj   +1 more source

Burst firing in a motion-sensitive neural pathway correlates with expansion properties of looming objects that evoke avoidance behaviours

open access: yesFrontiers in Integrative Neuroscience, 2015
The locust visual system contains a well-defined motion-sensitive pathway that transfers visual input to motor centers involved in predator evasion and collision avoidance.
Glyn Allan McMillan, John R Gray
doaj   +1 more source

Critical Bursts in Filtration [PDF]

open access: yesPhysical Review Letters, 2018
7 pages, 9 ...
Bianchi, F   +3 more
openaire   +6 more sources

Rinzel classification of bursting patterns.

open access: yes, 2022
Square-wave bursting, here in the Hindmarsh–Rose model [40] (panels (a1)-(b1)); elliptic bursting, here in the FitzHugh–Rinzel model [6,41] (panels (a2)-(b2)); parabolic bursting, here in Plant’s model [42] (panels (a3)-(b3)).
Mathieu Desroches (642822)   +2 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

The Effect of Learning on Bursting [PDF]

open access: yesIEEE Transactions on Biomedical Engineering, 2009
We have studied the effect that learning a new stimulus-response (SR) relationship had within a neuronal network cultured on a multielectrode array. For training, we applied repetitive focal electrical stimulation delivered at a low rate (
Stegenga, J.   +3 more
openaire   +4 more sources

Simple models of bursting and non-bursting P-type electroreceptors [PDF]

open access: yes, 2001
Weakly electric "sh use phase and amplitude modulations of their electric organ discharge to communicate and to capture prey (electrolocation).
Andreh Longtin   +3 more
core   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif   +17 more
wiley   +1 more source

On the Number of Coexisting Autowaves in the Chain of Coupled Oscillators

open access: yesМоделирование и анализ информационных систем, 2014
We consider a model of neuron complex formed by a chain of diffusion coupled oscillators. Every oscillator simulates a separate neuron and is given by a singularly perturbed nonlinear differential-difference equation with two delays.
Y. V. Bogomolov   +2 more
doaj   +1 more source

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