Results 111 to 120 of about 37,656 (267)
Variation-resilient spike-timing-dependent plasticity in memristors using bursting neuron circuit
Neuromorphic Computing and EngineeringSpike-timing-dependent plasticity (STDP) is a classic synaptic function that facilitates learning and memory in a biological brain. Hardware implementation of neural circuits supporting dynamical STDP functions offers notable advantages in terms of ...
Yize Liu +7 more
doaj +1 more source
Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer
Advanced Science, EarlyView.The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu +13 more
wiley +1 more source
Advanced Science, EarlyView.Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao +9 more
wiley +1 more source
Advanced Science, EarlyView.We proposed a method based on the piezoelectric effect and fabricated an implant abutment on the basis of piezoelectric ceramic. Under physiological occlusal pressure, the oral motion‐powered smart dental implant abutments interacted with water and oxygen, promoting the formation of reactive oxygen species and achieving a synergistic and highly ...
Xiyu Shi +15 more
wiley +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Design of monitoring and control system for water bursting in floor of coal seam
Gong-kuang zidonghua, 2013 In order to solve problems of existing water bursting prevention methods such as large difference between theoretical parameters and actual environmental parameters, poor advanced forecast and real-time performance and so on, the paper proposed a design ...
LI Cai-ping +2 more
doaj
Advanced Science, EarlyView.Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang +10 more
wiley +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
A Fentanyl‐Responsive Microneedle Patch for Harm Reduction
Advanced Science, EarlyView.A fentanyl‐responsive microneedle patch is developed as a self‐regulating overdose intervention that releases naloxone upon detecting fentanyl. The system employs aptamer‐functionalized nanoparticles embedded in a swellable polymer matrix to enable rapid, on‐demand drug delivery through the skin.
Penghui Zhao +10 more
wiley +1 more source