Results 51 to 60 of about 943 (203)

The Serotonin 2B (5‐HT2B) Receptor: A Narrative Review of Preclinical and Clinical Evidence on the Safety Considerations and Therapeutic Potential for the Treatment of Depression

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder (MDD) and treatment‐resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor‐level treatment strategies beyond monoamine reuptake. The serotonin 5‐HT2B receptor (5‐HT2BR) is uniquely positioned at the interface of central‐antidepressant mechanisms and peripheral cardiac risks.
Gia Han Le, Sabrina Wong, Danica E. Johnson, Diana K. Orsini, Yang Jing Zheng, Kayla M. Teopiz, Christine E. Dri, Joshua D. Rosenblat, Roger S. McIntyre   +8 more
wiley   +1 more source

Experimental Investigation on the Influence of Temperature on Coal and Gas Outbursts

, 2023
With the increasing mining depth, the dynamic disaster of coal and gas outbursts in coal mines has become increasingly prominent, and the bursting liability of coal and rock mass in deep coal seam mining is a necessary condition for the occurrence of ...
Xiaohan Qi, Shengnan Li, Heng Ma, Xiaoqi Wang   +3 more
core   +1 more source

The hyperpolarization‐activated cyclic nucleotide‐gated 4 channel as a potential anti‐seizure drug target [PDF]

, 2020
Background and Purpose Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are encoded by four genes (HCN1–4) with distinct biophysical properties and functions within the brain.
M. Novella Romanelli, Ludwig, A, Phillips, AM, Nicolazzo, JA, Jin, L, Bleakley, LE, Jia, L, Lauren E. Bleakley, Joseph A. Nicolazzo, Qays Kharouf, Christopher A. Reid, Morrisroe, E, Emma Morrisroe, Elisabetta Cerbai, Petrou, S, Andreas Ludwig, Romanelli, MN, Linghan Jia, A. Marie Phillips, Liang Jin, Kharouf, Q, Reid, CA, Oyrer, J, Julia Oyrer, Steven Petrou, Cerbai, E   +25 more
core   +1 more source

Reduced occurrence of alpha waves during resting state predicts high attention‐deficit/hyperactivity disorder traits in young adults

JCPP Advances, EarlyView.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) is a neurodevelopmental condition with significant cognitive and social impacts. Identifying reliable biomarkers for ADHD is crucial for developing personalised therapies. Electroencephalography (EEG) alpha oscillations (8–12 Hz) have been suggested as a potential biomarker, but ...
Julio Rodriguez‐Larios, Ümit Aydin, Gráinne McLoughlin   +2 more
wiley   +1 more source

Classification criteria for coal bursting liability based on scratch testing

Meitan kexue jishu
The bursting liability is an inherent property of coal-rock masses prone to impact failure, serving as an intrinsic factor for coal mines to induce rockburst accidents and a critical indicator for assessing the risk of rockburst. However, the traditional
Yixin ZHAO, Tao WANG, Zhe YANG, Ronghuan XIE   +3 more
doaj   +1 more source

Incorporation of Natural Antimicrobial Agents Into Thermoplastic Polymers for Food Applications: Strategies, Efficacy, Challenges and Future Directions

Packaging Technology and Science, EarlyView.
This graphical abstract summarizes the main strategies for incorporating natural antimicrobial agents into thermoplastic food packaging polymers, including melt processing, surface deposition, controlled release and chemical immobilization. It highlights the major classes of natural antimicrobials, key advantages such as microbial growth reduction and ...
Florence Akinmeye, Fabrice Gouanve, Fatima Zahra Jamal, Abdelkader Selmi, Sami Ghnimi   +4 more
wiley   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Experimental study on the evolution patterns of bursting liability of hard and brittle sandstone under microwave thermal shock

矿业科学学报
Rock burst is a major disaster in deep mining, where bursting liability is an important indicator of rock burst risk. This study therefore intends to explore the impact of microwave thermal shock on rocks with strong bursting liability by testing the ...
TENG Teng, JIA Wenjian, YI Peng, ZHAO Yixin, ZHU Xiaoyan, XU Duo   +5 more
doaj   +1 more source

Home foreclosure discounts in auctions without reserve prices

Real Estate Economics, EarlyView.
Abstract This article estimates foreclosure discounts in Cape Town, South Africa, where, until 2019, foreclosure auctions occurred without reserve prices. Using newly constructed data linking sheriff auction notices to the universe of property transactions, rich property characteristics, and municipal service‐request records, I document large ...
Allan Davids
wiley   +1 more source

Illiquidity and All Its Friends [PDF]

, 2009
The recent crisis was characterized by massive illiquidity. This paper reviews what we know and don't know about illiquidity and all its friends: market freezes, fire sales, contagion, and ultimately insolvencies and bailouts.
Jean Tirole, TIROLE, Jean
core   +1 more source